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MDM4 structure is subject to extensive post-transcriptionally modification. Human MDM4 is comprised of an N-terminal p53-binding domain, a central domain with an acidic region and a Zn finger, and a C-terminal RING domain. MDM4 undergoes post-transcriptional phosphorylations, which are designated by ‘P’, at either tyrosine ‘Y’ or serine ‘S’. The specific kinases (orange color) and phosphatase (mauve color) that modify MDM4 dictate its activity temporarily and spatially.
