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p53 regulation of the apoptotic cell death pathways. Cell death regulators encoded by direct p53 target genes and transcriptionally induced are outlined in a solid red box; those encoded by indirect p53 target genes and induced are outlined in a dashed red box; those encoded by indirect p53 target genes and repressed are outlined in a dashed blue box; other cell death regulators (not controlled by p53) are outlined in grey.
