| Methods | See aa Beutner 1979a | |
| Participants | ||
| Interventions | ||
| Outcomes | ||
| Funding Source | ||
| Notes | ||
| Risk of bias | ||
| Bias | Authors' judgement | Support for judgement |
| Random sequence generation (selection bias) | Low risk | Random number |
| Allocation concealment (selection bias) | Low risk | Coded identical looking compounds |
| Blinding (performance bias and detection bias) All outcomes | Low risk | Double‐blinding |
| Incomplete outcome data (attrition bias) All outcomes | Low risk | No losses to follow‐up |
| Summary assessments | Low risk | Plausible bias unlikely to seriously alter the results |
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