ca Vasil'eva 1982

Methods	Comparative cohort study of a monovalent injected vaccine in children aged 7 to 15 years in Leningrad, former USSR. The setting, season and viral circulation are not described
Participants	335 children of unknown provenance
Interventions	Monovalent inactivated vaccine containing A/Texas/1/77 (H3N2) (Leningrad Louis Pasteur laboratories) subcutaneous or by needless injector or placebo. Placebo is not described
Outcomes	Serological Paired sera taken in a non‐described fashion. There were antibody rises to other influenza A viruses and PIV 1 in the placebo arm Effectiveness ILI described in the translation as "influenza and URTI". Breakdown by age groups and type of injection is not reported Safety Temperature, induration, headache, malaise, sore throat. Daily physical examinations for 5 days
Funding Source	Unclear
Notes	The authors conclude that the vaccine (incidence in the arms was 1.8 and 9.9 respectively) was effective, immunogenic and safe. Very brief report. There is no description of randomisation, allocation or attrition. The authors briefly described evidence of A/Khabarovsk/77, A/Texas/77 and PIV 1 circulation in the placebo arm which could account for some of the febrile episodes
Risk of bias
Bias	Authors' judgement	Support for judgement
PCS/RCS‐Selection Exposed cohort	Unclear risk	Not described
PCS/RCS‐Selection Non Exposed cohort	Unclear risk	Not described
PCS/RCS‐Comparability	Unclear risk	Not described
PCS/RCS‐Assessment of Oucome	Unclear risk	Not described
Summary assessments	High risk	Insufficient information to assess study design