| Methods |
Op
P |
| Participants |
N 361 (80% Caucasian)
Pregnant women, Normotension
Age 27.5 |
| Interventions |
SR 40 (124‐84)
Dur 35 (mean duration) |
| Outcomes |
DBP |
| Notes |
LoFo: 67. IT: No |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Random sequence generation (selection bias) |
Unclear risk |
Insufficient information |
| Allocation concealment (selection bias) |
Low risk |
Block randomisation. Treatment allocation in opaque sealed envelopes. |
| Blinding (performance bias and detection bias)
All outcomes |
High risk |
Open study |
| Incomplete outcome data (attrition bias)
All outcomes |
High risk |
Lost to follow up LS: 35/184; US: 32/177 |
| Selective reporting (reporting bias) |
High risk |
SBP effect not reported |
| Blinding of participants and personnel (performance bias)
All outcomes |
High risk |
Open study: Performance bias due to knowledge of the allocated interventions by participants and personnel during the study. |
| Blinding of outcome assessment (detection bias)
All outcomes |
High risk |
Open study: Detection bias due to knowledge of the allocated interventions by outcome assessors |
