1213 Mallamaci 2013.

Methods	Op, CO
Participants	N 32 (M/F:23/9)(B/W/A.0/32/0) Hypertension Age 48
Interventions	SR 165 Dur 14
Outcomes	SBP, DBP, renin, aldo
Notes	32 of 102 screened were randomized. LoFo: 0
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Insufficient information
Allocation concealment (selection bias)	Unclear risk	Insufficient information
Blinding (performance bias and detection bias) All outcomes	High risk	Open study
Incomplete outcome data (attrition bias) All outcomes	Low risk	Lost to follow up 0/32
Selective reporting (reporting bias)	Low risk	No distinct selective outcome reporting
Blinding of participants and personnel (performance bias) All outcomes	High risk	Open study: Performance bias due to knowledge of the allocated interventions by participants and personnel during the study.
Blinding of outcome assessment (detection bias) All outcomes	Low risk	Outcome detection blinded