| 1 Lung function (% predicted) |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Totals not selected |
| 1.1 FEV₁ at 6 years |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
| 1.2 FVC at 6 years |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
| 2 Number of children from whom S aureus isolated at least once |
3 |
|
Odds Ratio (M‐H, Fixed, 95% CI) |
Subtotals only |
| 2.1 1 year |
2 |
248 |
Odds Ratio (M‐H, Fixed, 95% CI) |
0.27 [0.15, 0.48] |
| 2.2 2 years |
3 |
315 |
Odds Ratio (M‐H, Fixed, 95% CI) |
0.21 [0.13, 0.35] |
| 2.3 3 years |
2 |
260 |
Odds Ratio (M‐H, Fixed, 95% CI) |
0.22 [0.13, 0.38] |
| 2.4 4 years |
1 |
127 |
Odds Ratio (M‐H, Fixed, 95% CI) |
0.10 [0.04, 0.25] |
| 2.5 5 years |
1 |
98 |
Odds Ratio (M‐H, Fixed, 95% CI) |
0.09 [0.03, 0.26] |
| 2.6 6 years |
1 |
43 |
Odds Ratio (M‐H, Fixed, 95% CI) |
0.11 [0.03, 0.46] |
| 3 Z score weight |
2 |
|
Mean Difference (IV, Fixed, 95% CI) |
Subtotals only |
| 3.1 6 months |
1 |
32 |
Mean Difference (IV, Fixed, 95% CI) |
0.30 [‐0.54, 1.14] |
| 3.2 1 year |
2 |
133 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.12 [‐0.50, 0.26] |
| 3.3 2 years |
2 |
140 |
Mean Difference (IV, Fixed, 95% CI) |
0.06 [‐0.33, 0.45] |
| 3.4 3 years |
1 |
112 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.14 [‐0.58, 0.30] |
| 4 Z score length |
2 |
|
Mean Difference (IV, Fixed, 95% CI) |
Subtotals only |
| 4.1 6 months |
1 |
23 |
Mean Difference (IV, Fixed, 95% CI) |
0.52 [‐0.36, 1.40] |
| 4.2 1 year |
2 |
127 |
Mean Difference (IV, Fixed, 95% CI) |
0.06 [‐0.36, 0.48] |
| 4.3 2 years |
2 |
134 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.23 [‐0.65, 0.19] |
| 4.4 3 years |
1 |
112 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.07 [‐0.50, 0.36] |
| 5 Number of children requiring admission (annualised rates) |
3 |
243 |
Odds Ratio (M‐H, Fixed, 95% CI) |
0.96 [0.50, 1.86] |
| 6 Days in hospital (annualised rates) |
3 |
242 |
Mean Difference (IV, Fixed, 95% CI) |
0.88 [‐1.35, 3.10] |
| 7 Number of children receiving additional antibiotics |
1 |
|
Odds Ratio (M‐H, Fixed, 95% CI) |
Totals not selected |
| 8 Days of additional antibiotics |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Totals not selected |
| 9 Number of children from whom H influenzae isolated at least once |
1 |
|
Odds Ratio (M‐H, Fixed, 95% CI) |
Totals not selected |
| 9.1 2 years |
1 |
|
Odds Ratio (M‐H, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
| 10 Number of children from whom P aeruginosa isolated at least once |
3 |
|
Odds Ratio (M‐H, Fixed, 95% CI) |
Subtotals only |
| 10.1 1 year |
2 |
247 |
Odds Ratio (M‐H, Fixed, 95% CI) |
1.42 [0.77, 2.60] |
| 10.2 2 years |
3 |
315 |
Odds Ratio (M‐H, Fixed, 95% CI) |
0.74 [0.45, 1.23] |
| 10.3 3 years |
2 |
261 |
Odds Ratio (M‐H, Fixed, 95% CI) |
0.88 [0.51, 1.51] |
| 10.4 4 years |
1 |
127 |
Odds Ratio (M‐H, Fixed, 95% CI) |
1.28 [0.62, 2.64] |
| 10.5 5 years |
1 |
98 |
Odds Ratio (M‐H, Fixed, 95% CI) |
1.97 [0.85, 4.58] |
| 10.6 6 years |
1 |
43 |
Odds Ratio (M‐H, Fixed, 95% CI) |
3.67 [0.77, 17.35] |
| 11 Adverse effects: mean number of days experiencing adverse effect |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Totals not selected |
| 11.1 Generalised rash |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
| 11.2 Nappy rash |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
| 11.3 Increased stool frequency |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
| 12 Shwachman score |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Totals not selected |
| 12.1 3 years |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
| 13 Chrispin‐Norman Score |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Totals not selected |
| 13.1 3 years |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
