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. 2017 Apr 10;2017(4):CD011793. doi: 10.1002/14651858.CD011793.pub2

NCT01972555 (CMILE).

Methods Study design: open‐label, randomised controlled trial
Duration: 22 months
No. of centres: single
Location: Sweden
Setting: cardiac surgical centre
Dates: October 2013 to July 2015
Participants 40 consecutive participants undergoing first‐time elective isolated AVR.
Exclusion criteria: LVEF < 0.45; coexisting severe valvular disorder; previous cardiac surgery; urgent or emergent surgery
Interventions Limited sternotomy: either mini‐sternotomy or anterior right‐sided mini‐thoracotomy
Outcomes Primary outcomes: tricuspid annular systolic plane excursion; right ventricular fractional area change; right ventricular dimensions; pulsed wave tissue Doppler right ventricular velocity (all at postoperative days 4 and 40)
Secondary outcomes: not stated
(follow‐up time in parentheses)
Notes Principle investigator contacted for results (October 2016).

AVR: aortic valve replacement; COPD: chronic obstructive pulmonary disease; LVEF: left ventricular ejection fraction.