NCT02272621.

Trial name or title	Surgical Trauma After Partial Upper Hemisternotomy Versus Full Sternotomy Aortic Valve Replacement
Methods	Study design: open‐label, randomised, controlled trial Duration: 20 months No. of centres: single Location: Sweden Setting: cardiac surgical centre Dates: April 2014 to December 2016
Participants	40 participants scheduled for aortic valve replacement Inclusion criteria: aged ≥ 18 years; severe aortic stenosis defined as aortic valve area of < 1 cm2 or index area of 0.6 cm2/m2 by echocardiography; referred for medically indicated aortic valve replacement; sinus rhythm; provide written informed consent Exclusion criteria: left ventricular ejection fraction < 0.45; presence of any coexisting severe valvular disorder; previous cardiac surgery; urgent or emergent surgery
Interventions	Partial upper hemi‐sternotomy
Outcomes	Primary outcomes: interleukin‐6; interleukin‐8; interleukin‐10; tumour necrosis factor‐alpha. All postoperatively at 0 to 3 days
Starting date	April 2015
Contact information	Peter Svenarud, MD, PhD +46 (0) 8 517 708 12 peter.svenarud@karolinska.se
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