Table 3.

Results of analysis (heterogeneity, overall effect and interaction)

	Statistic	Time to withdrawal of allocated treatment	Time to achieve 12‐month remission	Time to achieve six‐month remission	Time to first seizure
Test for heterogeneity	Chi²	(df = 5) 5.95	(df = 3) 0.19	(df = 4) 1.66	(df = 4) 4.23
	P value	0.31	0.98	0.80	0.38
	I²	16%	0%	0%	5%
Overall effect	HR (95% CI)	1.02 (0.73 to 1.49)	0.97 (0.77 to 1.22)	0.92 (0.76 to 1.12)	0.96 (0.78 to 1.18)
	P value	0.92	0.81	0.42	0.70
Test for interaction between treatment and epilepsy type	Chi²	(df = 1) 0.31	(df = 1) 0.39	(df = 1) 0.13	(df = 1) 1.06
	P value	0.58	0.53	0.72	0.3
	I²	0%	0%	0%	5.6%
Overall effect adjusted for epilepsy type	HR (95% CI)	1.09 (0.76 to 1.55)	0.98 (0.78 to 1.23)	0.95 (0.78 to 1.15)	0.93 (0.75 to 1.14)
	P value	0.19	0.87	0.60	0.47

CI: confidence interval; df: degrees of freedom of Chi² distribution; HR: Hazard ratio; P < 0.05 is classified as statistically significant