Bath 2001.

Methods	Double‐blind, placebo‐controlled Randomisation by computer (minimisation by age, mean arterial BP, baseline SSS, hours from onset, presence of stroke lesion on CT)
Participants	UK, single centre 37 participants: treatment 16; control 21 Age: treatment 76 years; control 72 years Male: treatment 6 (38%); control; 12 (57%) Inclusion: IS or ICH Time to randomisation: within five days of onset
Interventions	Treatment: transdermal GTN patch 5 mg once daily Control: matching placebo Duration: 12 days
Outcomes	Primary: BP on day 1 (24 hour ambulatory BP measured 3 times per hour during the day and hourly at night at days 0, 1, 8) Secondary: death at end of treatment; death or dependency (mRS > 2), death, and BI at 3 months
Notes	Exclusion: taking part in another trial
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Computer randomisation with minimisation
Allocation concealment (selection bias)	Low risk	Computer randomisation with minimisation
Blinding (performance bias and detection bias) All outcomes	Low risk	Matching treatment and placebo patches
Blinding of participants and personnel (performance bias) All outcomes	Low risk	Matching treatment and placebo patches
Blinding of outcome assessment (detection bias) All outcomes	Low risk	Outcomes assessed blinded to treatment group
Incomplete outcome data (attrition bias) All outcomes	Low risk	No differences between trial groups
Selective reporting (reporting bias)	Low risk	All prespecified outcomes reported
Other bias	Low risk	None found