RIGHT‐2 2015.

Trial name or title	Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial‐2 (RIGHT‐2)
Methods	Prospective multicentre single‐blind randomised controlled trial
Participants	850 participants Inclusion: FAST positive test, BP ≥ 120 mmHg, presenting to ambulance service following a 999 emergency call Time to randomisation: within 4 hours of onset
Interventions	Treatment: transdermal GTN patch 5 mg once daily Control: sham patch (Blinding with gauze dressing over patch) Duration: 4 days
Outcomes	Primary: mRS at 90 days Secondary: Hospital admission: NIHSS; systolic BP, DBP, HR; stroke lesion size on CT Day 2‐4: systolic BP, diastolic BP, HR; NIHSS; recurrent stroke; death; hypotension; neurological deterioration (NIHSS ≥ 4 points or ≥ 2 point increase in any domain) Discharge/death: length of stay; patient disposition Day 90 and 365: mRS; BI; EQ‐5D, EQ‐VAS; MMSE; TICS‐M; animal naming; Zung Depression Scale; stroke recurrence
Starting date	October 2015
Contact information	Philip Bath, Stroke Association Professor of Stroke Medicine, Stroke, Division of Clinical Neuroscience, B52, Clinical Sciences Building, University of Nottingham, City Hospital Campus, Hucknall Road, Nottingham, NG5 1PB (philip.bath@nottingham.ac.uk)
Notes

BI: Barthel index
 BP: Blood pressure
 CT: Computed tomography
 DBP: Diastolic blood pressure
 EQ‐5D: European quality of life‐5 dimensions
 EQ‐VAS: European quality of life‐visual analogue scale
 GTN: Glyceryl trinitrate
 HR: Heart rate
 ICH: Intracerebral haemorrhage
 IS: Ischaemic stroke
 MMSE: Mini‐mental state examination
 MRI: Magnetic resonance imaging
 mRS: Modified Rankin scale
 NIHSS: National Institutes of Health Stroke Scale
 QoL: Quality of life
 SBP: Systolic blood pressure
 SSS: Scandanavian stroke scale
 TICS‐M: modified Telephone Interview for Cognitive Status