Comparison 5. Lower versus higher targeted oxygen saturations (primary outcome, subgrouped by oximeter calibration software).

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Death or major disability by 18 to 24 months corrected age (aligned definition)	5	4684	Risk Ratio (M‐H, Fixed, 95% CI)	1.04 [0.98, 1.10]
1.1 Original algorithm	5	3003	Risk Ratio (M‐H, Fixed, 95% CI)	1.00 [0.94, 1.07]
1.2 Revised algorithm	3	1681	Risk Ratio (M‐H, Fixed, 95% CI)	1.13 [1.02, 1.24]
2 Death or major disability by 18 to 24 months corrected age (trialist defined)	5	4681	Risk Ratio (M‐H, Fixed, 95% CI)	1.07 [1.00, 1.15]
2.1 Original algorithm	5	3000	Risk Ratio (M‐H, Fixed, 95% CI)	1.04 [0.95, 1.13]
2.2 Revised algorithm	3	1681	Risk Ratio (M‐H, Fixed, 95% CI)	1.13 [1.02, 1.24]