Crombleholme 1986

Methods	Randomized controlled trial.
Participants	Inclusion criteria: severe acute PID with peritonitis, tubo‐ovarian abscess, endometritis, and pelvic cellulitis. Exclusion criteria: not stated. Number of women randomized: 39; group A: 20; group B: 19. Number of women analyzed: 39; group A: 20; group B: 19. Number of withdrawals/exclusions/loss to follow‐up and reasons: not stated. Number of centres: not stated. Age (years): not stated. Country: not stated.
Interventions	Group A: sulbactam 1 g + ampicillin 2 g IV every 6 h. Group B: metronidazole 15 mg/kg loading followed by 7.5 mg/kg IV every 6 h and gentamicin 1.5 mg/kg IV every 8 h. Antibiotics in both groups continued for minimum of 5 days.
Outcomes	No relevant outcomes reported for our analysis because the outcomes were not separately reported for the different diagnoses within the study groups. Authors stated clinical cure occurred in 19/20 women in group A and 16/19 women in group B.
Notes	Ethical approval: not stated. Informed consent: not stated. Source of funding: not stated, and no conflicts of interest reported. 2 cases of posthysterectomy pelvic cellulitis were included in the analysis.
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Not stated.
Allocation concealment (selection bias)	Unclear risk	Not stated.
Blinding of participants and personnel (performance bias) All outcomes	High risk	Non‐blinded study.
Blinding of outcome assessment (detection bias) All outcomes	High risk	Non‐blinded study.
Incomplete outcome data (attrition bias) All outcomes	Low risk	All women randomized were analyzed.
Selective reporting (reporting bias)	Unclear risk	No trial protocol found.
Other bias	Unclear risk	Not stated.