| Trial name or title | The Importance of Anti‐anaerobic Therapy for Acute Pelvic Inflammatory Disease (PID). |
| Methods | Randomized placebo‐controlled trial comparing 2 antibiotic treatment regimens for acute PID: group A: ceftriaxone + doxycycline; group B: ceftriaxone + doxycycline + metronidazole for 14 days. |
| Participants | Women aged 15‐40 years. |
| Interventions | Group A: ceftriaxone 250 mg IM single dose + doxycycline 100 mg PO twice daily × 14 days + placebo PO twice daily × 14 days. Group B: ceftriaxone 250 mg IM single dose + doxycycline 100 mg PO twice daily × 14 days + metronidazole 500 mg PO twice daily × 14 days. |
| Outcomes | Clearance of anaerobic organisms from the endometrium (over 30 days) (designated as safety issue: no). Follow‐up: 1 month for clinical outcomes, and assessment for clearance of microorganisms from the upper genital tract. |
| Starting date | November 2010. |
| Contact information | Harold Wiesenfeld, Associate Professor, University of Pittsburgh. |
| Notes |
IM: intramuscular; PID: pelvic inflammatory disease; PO: per os.