Aysan 2008.

Study characteristics
Patient sampling	Type of study: prospective study. Consecutive or random sample: unclear.
Patient characteristics and setting	Sample size: 99. Females: 46 (46.5%). Median or median age: 37 years. Presentation: Patients with abdominal pain. Exclusion criteria: Patients with trauma or who required emergency surgical intervention. Setting: secondary care, Turkey.
Index tests	Index test: urinary trypsinogen‐2. Further details: Technical specifications: Medix Biochemica. Performed by: not stated. Criteria for positive diagnosis: not clearly stated (probably used the manufacturer's level of > 50 ng/mL).
Target condition and reference standard(s)	Target condition: acute pancreatitis. Reference standard: CT scan. Further details: Technical specifications: not stated. Performed by: radiologists. Criteria for positive diagnosis: at least 1 of the following: increase in diameter of pancreas; irregular pancreas contours; peripancreatic fluid; peripancreatic gas accumulation.
Flow and timing	Number of indeterminates for whom the results of reference standard were available: not stated. Number of patients who were excluded from the analysis: not stated.
Comparative
Notes
Methodological quality
Item	Authors' judgement	Risk of bias	Applicability concerns
DOMAIN 1: Patient Selection
Was a consecutive or random sample of patients enrolled?	Unclear
Was a case‐control design avoided?	Yes
Did the study avoid inappropriate exclusions?	Unclear
		Unclear	Unclear
DOMAIN 2: Index Test Urinary trypsinogen‐2 (standard criteria)
Were the index test results interpreted without knowledge of the results of the reference standard?	Unclear
If a threshold was used, was it pre‐specified?	Yes
		Unclear	Unclear
DOMAIN 3: Reference Standard
Is the reference standards likely to correctly classify the target condition?	No
Were the reference standard results interpreted without knowledge of the results of the index tests?	Unclear
Is the reference standard independent of the index test?	Yes
		High	Low
DOMAIN 4: Flow and Timing
Was there an appropriate interval between index test and reference standard?	Unclear
Did all patients receive the same reference standard?	Yes
Were all patients included in the analysis?	Unclear
Did all patients receive a reference standard?	Yes
		Unclear