Burkitt 1987.
| Study characteristics | |||
| Patient sampling | Type of study: prospective study. Consecutive or random sample: neither. | ||
| Patient characteristics and setting | Sample size: 306.
Females: not stated.
Median or median age: not stated.
Presentation:
People with abdominal pain. Note: 88 patients who had normal urinary amylase were excluded from analysis. Setting: seconday care, UK. |
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| Index tests | Index test: urinary amylase.
Further details:
Technical specifications: Rapignost‐Amylase test.
Performed by: not stated.
Criteria for positive diagnosis: 1 plus. Second criteria for positive diagnosis: 2 plus. |
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| Target condition and reference standard(s) | Target condition: acute pancreatitis. Reference standard: Phadebas Amylase > 1000 (normal limit 300) + abdominal pain. Further details: Technical specifications: not stated. Performed by: not stated. Criteria for positive diagnosis: amylase > 1000 (normal limit 300) + abdominal pain. | ||
| Flow and timing | Number of indeterminates for whom the results of reference standard were available: not stated. Number of patients who were excluded from the analysis: 88 (28.8%). | ||
| Comparative | |||
| Notes | |||
| Methodological quality | |||
| Item | Authors' judgement | Risk of bias | Applicability concerns |
| DOMAIN 1: Patient Selection | |||
| Was a consecutive or random sample of patients enrolled? | No | ||
| Was a case‐control design avoided? | Yes | ||
| Did the study avoid inappropriate exclusions? | Unclear | ||
| High | High | ||
| DOMAIN 2: Index Test Urinary amylase | |||
| Were the index test results interpreted without knowledge of the results of the reference standard? | Unclear | ||
| If a threshold was used, was it pre‐specified? | Unclear | ||
| Unclear | Low | ||
| DOMAIN 3: Reference Standard | |||
| Is the reference standards likely to correctly classify the target condition? | Yes | ||
| Were the reference standard results interpreted without knowledge of the results of the index tests? | Unclear | ||
| Is the reference standard independent of the index test? | Yes | ||
| Unclear | Low | ||
| DOMAIN 4: Flow and Timing | |||
| Was there an appropriate interval between index test and reference standard? | Yes | ||
| Did all patients receive the same reference standard? | Yes | ||
| Were all patients included in the analysis? | Unclear | ||
| Did all patients receive a reference standard? | Yes | ||
| Unclear | |||