Study	Reason for exclusion
Abascal 1982	No diagnostic test accuracy data
Abate 1979	Inappropriate population
Acero 1982	Case‐control study
Adam 1986	No diagnostic test accuracy data
Adams 1968	No diagnostic test accuracy data
Adler 1985	Inappropriate reference standard
Ahmed 2009	Inappropriate population
Aho 1988	No diagnostic test accuracy data
Aho 1989	No diagnostic test accuracy data
Alvarez 1998	Not a primary research study
Anand 1956	Inappropriate population
Andersen 2010	Case‐control study
Andre 1967	Inappropriate population
Andren‐Sandberg 1997	Not a primary research study
Andriushchenko 1998	Inappropriate population
Anonymous 1966	Not a primary research study
Anonymous 2012	Not a primary research study
Aparisi 1987	Not a primary research study
Apple 1991	Inappropriate reference standard
Arzoglou 1983	Inappropriate population
Arzoglou 1986	Case‐control study
Bacchini 1980	Inappropriate population
Bachmann 1979	Case‐control study
Baillie 1997	Not a primary research study
Baillie 1998	Not a primary research study
Bang 2016	Inappropriate population
Banks 1996	Inappropriate population
Barbado 1977	Case‐control study
Barbieri 2016	Not a primary research study
Bargum 1983	No diagnostic test accuracy data
Barnett 1986	Inappropriate population
Batra 2015	Inappropriate population
Batsakis 1965	Not a primary research study
Benini 1987	Inappropriate reference standard
Benini 1987a	Inappropriate population
Benini 1992	Inappropriate reference standard
Berger 1976	Case‐control study
Bernard 1959	No diagnostic test accuracy data
Bernard 1964	Not a primary research study
Bernard 1964a	Not a primary research study
Bernard 1964b	Not a primary research study
Berry 1982	Inappropriate population
Blamey 1983	Inappropriate population
Bluskina 1966	Case‐control study
Bode 1987	Not a primary research study
Borda 1978	Case‐control study
Borgstrom 1984	Inappropriate population
Borgstrom 2002	Not a primary research study
Bowen 1983	Inappropriate population
Brailski 1975	Not a primary research study
Branford 1948	No diagnostic test accuracy data
Brault 1985	Inappropriate population
Brisinda 1999	Inappropriate population
Brkic 1966	Not a primary research study
Brodie 1977	Inappropriate population
Brohee 1980	Inappropriate population
Brohee 1981	Not a primary research study
Brohee 1987	Not a primary research study
Brunner 1980	Not a primary research study
Buchler 1986	Inappropriate population
Budd 1959	Inappropriate population
Bunodiere 1975	Inappropriate population
Butler 2000	Not a primary research study
Caillens 1980	Inappropriate target condition
Calkins 1968	Inappropriate population
Cameron 1973	Inappropriate population
Campbell 1979	Inappropriate population
Caputo 1983	Inappropriate population
Cases 1988	Inappropriate population
Cevik 2010	Case‐control study
Chase 1996	Inappropriate reference standard
Chen 1994	Case‐control study
Chen 2004	Not a primary research study
Chen 2005	Inappropriate reference standard
Cheng 2004	Inappropriate population
Cheung 2015	No diagnostic test accuracy data
Choi 2009	Case‐control study
Choudhary 2012	Not a primary research study
Christoforidis 2002	Inappropriate population
Chylinski 1972	Inappropriate population
Chylinski 1978	Inappropriate population
Cintra 1952	Inappropriate population
Cintra 1953	Inappropriate population
Clave 1995	Inappropriate reference standard
Close 1987	Not a primary research study
Coffey 2014	Inappropriate population
Coffey 2014a	Inappropriate population
Collins 1982	Case‐control study
Concepcion Martin 2013	Inappropriate population
Concepcion‐Martin 2016	No diagnostic test accuracy data
Corfield 1984	Inappropriate population
Cornett 2010	No diagnostic test accuracy data
Corsetti 1993	Inappropriate reference standard
Cote 1979	Inappropriate population
Courtois 1986	Inappropriate population
Dalgat 1986	Inappropriate population
Dankner 1951	Inappropriate population
Dati 1988	Not a primary research study
de Boer 1986	Not a primary research study
De Leo 1954	Not a primary research study
Dehesa 1979	Case‐control study
Delcourt 1977	Not a primary research study
Deril 1989	Case‐control study
Deril 1992	Not a primary research study
Devanath 2009	Inappropriate population
Diaz 2009	Inappropriate population
Distefano 1952	No diagnostic test accuracy data
Domenech 1999	No diagnostic test accuracy data
Donaldson 1977	No diagnostic test accuracy data
Dreiling 1974	Inappropriate population
Dreiung 1954	Inappropriate population
Dronov 2009	Inappropriate population
Drozdov 2003	Not a primary research study
Durr 1977	Inappropriate population
Durr 1983	No diagnostic test accuracy data
Eckfeldt 1985	No diagnostic test accuracy data
Elman 1942	Not a primary research study
Engel 1977	No diagnostic test accuracy data
Ermini 1964	Not a primary research study
Esber 1995	Inappropriate population
Esperov 1972	Inappropriate population
Fabris 1976	No diagnostic test accuracy data
Farkas 1967	No diagnostic test accuracy data
Farrar 1978	Inappropriate population
Finke 1978	Inappropriate population
Fiocca 1983	Inappropriate population
Fiorucci 1986	Inappropriate population
Fishman 1955	Inappropriate population
Flamion 1987	Inappropriate population
Forell 1959	Inappropriate population
Forest 1990	Inappropriate reference standard
Fridhandler 1972	Inappropriate population
Frost 1978	Inappropriate population
Fruchart 1974	Inappropriate population
Fruchart 1980	Inappropriate population
Fujiki 1980	Inappropriate population
Fujita 1989	Inappropriate population
Fukumoto 1981	Inappropriate population
Gambill 1975	Not a primary research study
Garden 1985	No diagnostic test accuracy data
Gilbert 1955	No diagnostic test accuracy data
Gluskina 1965	Inappropriate population
Gomez 2012	Inappropriate population
Gonzalez 1978	Case‐control study
Grinblatt 1997	Not a primary research study
Grosberg 1979	Case‐control study
Gullo 2005	Not a primary research study
Gumaste 1991	Inappropriate population
Gumaste 1992	Case‐control study
Gumaste 1993	Case‐control study
Gumaste 1993a	Not a primary research study
Gungor 2011	Inappropriate population
Gunn 1986	Inappropriate population
Guth 1960	Inappropriate population
Gwozdz 1990	Inappropriate reference standard
Haas 1985	Inappropriate population
Haffter 1981	Case‐control study
Haffter 1983	Case‐control study
Hale 2015	Inappropriate population
Hathaway 1983	Case‐control study
Hayakawa 1985	Case‐control study
Hayakawa 1989	Case‐control study
Hedstroem 1998	Inappropriate reference standard
Hedstrom 1994	Case‐control study
Hedstrom 1996	Case‐control study
Hedstrom 1996a	Case‐control study
Hedstrom 1996b	Case‐control study
Hedstrom 1996c	Case‐control study
Hedstrom 2001	Case‐control study
Heer 1983	Case‐control study
Hegewald 1998	Inappropriate population
Hegewald 1999	Inappropriate population
Hegewald 2001	Inappropriate population
Hemingway 1988	Case‐control study
Hendry 1987	Inappropriate population
Henry 1957	Inappropriate population
Hoferichter 1964	Inappropriate population
Hoffman 1991	Inappropriate reference standard
Hofmeyr 2014	Inappropriate population
Holdsworth 1984	Case‐control study
Holmes 2011	Inappropriate population
Horanyi 1984	Inappropriate population
Hostein 1976	Inappropriate population
Hostein 1977	Inappropriate population
Hostein 1978	Inappropriate population
Houry 1985	Inappropriate reference standard
Houry 1989	Inappropriate reference standard
Huang 2010	Inappropriate population
Huguet 1993	Inappropriate reference standard
Husain 2004	Inappropriate population
Hwang 2004	Case‐control study
Ignjatovic 1997	Inappropriate reference standard
Ignjatovic 2000	Inappropriate reference standard
Im 2010	Inappropriate population
Imrie 1979	Inappropriate population
Ito 2007	Inappropriate population
Jacobson 1982	Not a primary research study
Jam 1978	Inappropriate population
Jang 2007	Inappropriate population
Jensen 1970	Inappropriate population
Jin 2012	Not a primary research study
Jin 2013	Not a primary research study
Jin 2013a	Not a primary research study
Johnson 2004	Inappropriate population
Jordanov 2009	Case‐control study
Joshi 2008	Inappropriate reference standard
Junge 1982	Case‐control study
Kaiser 1987	Inappropriate reference standard
Kamer 2007	Case‐control study
Kameya 1985	Case‐control study
Kameya 1986	Case‐control study
Kapetanos 2007	Inappropriate population
Karlsson 1979	Inappropriate population
Kaw 2001	Inappropriate population
Kazmierczak 1991	Inappropriate reference standard
Kehl 1985	Inappropriate population
Keim 2003	Case‐control study
Kemppainen 1997	Inappropriate reference standard
Kemppainen 1997a	Inappropriate population
Kemppainen 1997b	Inappropriate population
Kemppainen 1997c	Inappropriate reference standard
Kemppainen 1997d	Not a primary research study
Kerlin 1986	Inappropriate population
Khrapach 1992	Inappropriate population
Khvatova 1973	Inappropriate population
Kim 2015	Inappropriate population
King 1995	Inappropriate population
Kirchner 1976	Inappropriate population
Kitterer 2015	Inappropriate population
Kobayashi 2011	Inappropriate population
Koehler 1982	Inappropriate population
Kolars 1982	Inappropriate population
Kolars 1984	Inappropriate population
Kopacova 2010	Inappropriate population
Kubo 1975	Not a primary research study
Kulikovsky 2014	Inappropriate population
Kurti 2011	Inappropriate reference standard
Kusama 1956	Inappropriate population
Kutter 1983	Inappropriate population
Kylanpaa‐Back 1999	Inappropriate reference standard
Kylanpaa‐Back 2000	Inappropriate reference standard
Kylanpaa‐Back 2000a	Inappropriate reference standard
Kylanpaa‐Back 2002	Inappropriate reference standard
Lacher 1986	Inappropriate population
Lankisch 1977	Case‐control study
Lankisch 1977a	Case‐control study
Lankisch 1994	Inappropriate population
Lankisch 1994a	Inappropriate population
Lankisch 2006	Inappropriate population
Lankisch 2012	No diagnostic test accuracy data
Laurent‐Puig 1992	Inappropriate population
Lauschke 1963	Inappropriate population
Leclerc 1983	Inappropriate population
Lee 1995	Case‐control study
Lee 1996	Not a primary research study
Lempinen 2001	Inappropriate population
Lempinen 2003	Inappropriate population
Lessinger 1994	Case‐control study
Levitt 1975	Not a primary research study
Lifton 1974	Inappropriate population
Lifton 1974a	Inappropriate population
Ligny 1987	Case‐control study
Lin 1989	Case‐control study
Lindahl 1979	No diagnostic test accuracy data
Liyanage 2012	Inappropriate population
Logrono 2000	Inappropriate reference standard
Long 1976	Case‐control study
Loo 1992	Not a primary research study
Lott 1985	Not a primary research study
Lott 1985a	Not a primary research study
Lott 1986	Inappropriate population
Lott 1991	Not a primary research study
Lott 1991a	Case‐control study
Luengo 1996	Inappropriate population
Lunghi 1984	Inappropriate population
MacArthur 2013	Inappropriate population
Macgregor 1976	Case‐control study
Maekelae 1997	Inappropriate population
Majkicsingh 1986	Inappropriate population
Malfertheiner 1989	Inappropriate population
Mangano 1990	Inappropriate target condition
Marten 1976	Case‐control study
Masoero 1978	Inappropriate population
Masoero 1980	Case‐control study
Massey 1985	Inappropriate reference standard
Mayer 1985	Inappropriate reference standard
McCulloch 1984	Case‐control study
McIntosh 1976	Not a primary research study
McMahon 1981	Inappropriate population
McMahon 1982	Inappropriate population
Merina 1957	Inappropriate population
Millat 1999	Not a primary research study
Miller 1973	Inappropriate population
Millson 1998	Inappropriate reference standard
Mimoz 1993	Inappropriate population
Mingxin 2001	Inappropriate reference standard
Mirmiranyazdy 1995	Inappropriate population
Mohamed 1989	Case‐control study
Moller‐Petersen 1983	Inappropriate reference standard
Moller‐Petersen 1985	Inappropriate reference standard
Moller‐Petersen 1986	Inappropriate reference standard
Morel 1981	Case‐control study
Murray 1976	Inappropriate reference standard
Murray 1977	Inappropriate reference standard
Murray 1980	Inappropriate reference standard
Navarro 1984	Not a primary research study
Navarro 1987	Case‐control study
Nechai 1973	Inappropriate population
Nechiporuk 1982	Inappropriate population
Neoptolemos 1990	No diagnostic test accuracy data
Neoptolemos 1993	Not a primary research study
Neoptolemos 2000	Inappropriate population
Neovius 1984	Inappropriate reference standard
Neves 1985	Inappropriate population
Newland 2002	Inappropriate population
Oellerich 1983	Case‐control study
Orda 1982	Inappropriate reference standard
Orda 1984	Case‐control study
Orebaugh 1994	Inappropriate population
Osipov 1970	Inappropriate population
Ostrovskii 2012	Inappropriate population
Otsuki 1995	Case‐control study
Pace 1985	Inappropriate population
Pacheco 2003	Case‐control study
Pakkala 2012	Inappropriate population
Panteghini 1989	Inappropriate population
Panteghini 1990	Inappropriate population
Panteghini 1992	Inappropriate population
Papaioannou 1996	Case‐control study
Papp 1969	Case‐control study
Parodi 1983	Case‐control study
Pereiaslov 1999	Inappropriate population
Peromingo 2009	Inappropriate population
Pezzilli 1992	Case‐control study
Pezzilli 1992a	Case‐control study
Pezzilli 1994	Case‐control study
Pezzilli 1997	Inappropriate population
Pezzilli 1998	Case‐control study
Pezzilli 1999	Case‐control study
Pezzilli 1999a	Case‐control study
Pezzilli 2000	Case‐control study
Pezzilli 2001	Inappropriate population
Pezzilli 2004	Case‐control study
Phillip 2013	Inappropriate population
Pirolla 2015	Inappropriate population
Ponseti‐Bosch 1977	Case‐control study
Ponteziere 2001	Inappropriate reference standard
Popivanov 1963	No diagnostic test accuracy data
Protsenko 1966	No diagnostic test accuracy data
Raju 2003	Case‐control study
Raty 2007	Inappropriate population
Reilly 2011	Inappropriate population
Rick 1968	Inappropriate population
Roberts 1985	Case‐control study
Roberts 1987	Case‐control study
Rodriguez‐Cuartero 2000	No diagnostic test accuracy data
Rokicki 1976	Not a primary research study
Rosenblum 1991	Not a primary research study
Rosenburg 1957	No diagnostic test accuracy data
Rudis 2014	Inappropriate population
Ruzena 1989	No diagnostic test accuracy data
Sacchetti 1988	Inappropriate population
Sacchetti 1989	Inappropriate population
Sadowski 1992	Inappropriate population
Sainio 1995	Case‐control study
Sankaralingam 2007	Inappropriate population
Satz 1989	Case‐control study
Satz 1990	Case‐control study
Satz 1990a	Case‐control study
Saxon 1957	Case‐control study
Schmidt 2004	Inappropriate population
Scholz 1979	No diagnostic test accuracy data
Schultis 1969	No diagnostic test accuracy data
Schultis 1969a	Inappropriate reference standard
Schultis 1973	Case‐control study
Schwokowski 1979	Not a primary research study
Scottolini 1977	Not a primary research study
Serra 2011	Inappropriate population
Siede 1969	Not a primary research study
Singh 2002	Inappropriate population
Singh 2004	Inappropriate population
Smith 2005	Inappropriate population
Solomon 1978	Not a primary research study
Steinberg 1983	Inappropriate reference standard
Steinberg 1985	Case‐control study
Sternby 1996	Inappropriate population
Strebel 1970	Inappropriate population
Su 2010	Inappropriate reference standard
Suehiro 1984	Case‐control study
Sutton 2009	Inappropriate population
Szalaj 1973	Case‐control study
Testoni 1999	Inappropriate population
Testoni 1999a	Inappropriate population
Testoni 2001	Inappropriate population
Thomson 1987	Inappropriate reference standard
Ticktin 1965	Inappropriate population
Tietz 1986	Inappropriate population
Tomaszewski 1984	Inappropriate population
Torrens 1998	No diagnostic test accuracy data
Tournut 1978	Inappropriate population
Treacy 2001	Inappropriate population
Tsai 1988	Inappropriate population
Tseng 2011	Inappropriate population
Tvorogova 1991	Not a primary research study
Uhl 1992	Case‐control study
Uminska 1985	Case‐control study
Van Hee 1979	Case‐control study
Van Ingen 1992	Case‐control study
Varas 1994	Inappropriate population
Vega 1981	Inappropriate reference standard
Ventrucci 1983	Case‐control study
Ventrucci 1985	Inappropriate reference standard
Ventrucci 1986	Case‐control study
Ventrucci 1989	Case‐control study
Ventrucci 1992	Case‐control study
Ventrucci 1994	Case‐control study
Wajda 1978	Inappropriate population
Walker 2013	Inappropriate population
Waller 1971	Inappropriate population
Wang 2009	Inappropriate population
Warshaw 1975	Case‐control study
Weaver 1985	Inappropriate population
Werner 1989	Case‐control study
Wilson 2005	Case‐control study
Winslet 1990	Inappropriate population
Wyatt 1974	No diagnostic test accuracy data
Wyllie 1979	Inappropriate population
Xu 2008	Case‐control study
Xu 2010	Inappropriate reference standard
Yang 1987	Case‐control study
Yang 2005	Case‐control study
Zakrzewska 1982	Case‐control study
Zakrzewska 1985	Case‐control study
Zaninotto 1990	Case‐control study
Zastrow 1973	Inappropriate population
Zeng 2010	Not a primary research study
Zeze 1975	Case‐control study
Zhang 2010	Case‐control study
Zharkovskaia 1978	Inappropriate population
Zheltvai 1969	Not a primary research study