Summary of findings 4. Paediatric participants ‐ platelet count.
What is the diagnostic accuracy of platelet count? | ||||||
Review question | What is the diagnostic accuracy of platelet count for the diagnosis of oesophageal varices in paediatric people with liver disease or portal vein thrombosis? | |||||
Population | Children with diagnosis of chronic liver disease or portal vein thrombosis. Age < 18 years | |||||
Settings | Outpatients and inpatients in secondary/tertiary care setting | |||||
Study design | Prospective and retrospective cross‐sectional studies. No case‐control studies were found | |||||
Index tests | Platelet count | |||||
Reference standards | Upper endoscopy | |||||
Target condition | Summary accuracy (95% CI) | No. of participants (studies) |
Prevalence, Median (range ) |
Implications in a hypothetical cohort of 1000 people | Post‐test probability | Quality and comments |
Any varices Cut‐off value: around 120,000 /mm3 (range 115,000 to 119,000/mm3) |
Sensitivity 0.71 (0.60 to 0.80) Specificity 0.83 (0.70 to 0.91) LR+ 4.2 (2.4 to 7.3) LR‐ 0.35 (0.25 to 0.48) |
277 participants (4) | 58% (48% to 69%) | With a prevalence of 58%, 580 out of 1000 children will have varices of any size. Of these 580 children, 168 (29% of 580) children with varices will receive misdiagnosis and will not receive appropriate. prophylaxis or follow‐up The remaining 420 children will have no varices. 71 children (17% of 420) will receive false diagnosis of varices and will undergo an unnecessary endoscopy |
Assuming a pretest probability of 58% Post‐test probabilities:
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Studies were at high risk of bias |