Yoo 2012a.

Methods	Single‐centre, 2‐arm RCT Setting: University College of Medicine (Hospital) Country: Korea Groups: TIVA with propofol vs desflurane Period: November 2010‐ May 2011
Participants	Number: 62 Surgery: robotic‐assisted laparoscopic radical prostatectomy ‐ urology Included: male between 50 and 70 years of age with ASA I or II Excluded: history of motion sickness/PONV, use of antiemetics 24 hours before surgery, regular use of corticosteroids, chemotherapy within 4 weeks, radiotherapy within 8 weeks, hepatic dysfunction, confirmed renal impairment or obesity (BMI > 35 kg/m2)
Interventions	TIVA with propofol and remifentanil and antiemetic prophylaxis (n = 31) vs desflurane and remifentanil and antiemetic prophylaxis (n = 31) Procedure: robotic assisted laparoscopic radical prostatectomy
Outcomes	Incidence of nausea: reported Incidence of retching: reported Incidence of vomiting: reported Use of antiemetics: reported Severity of PONV: reported Intensity of pain ‐ VAS: reported Use of rescue analgesics: reported
Notes	A third arm with patients treated with TIVA without antiemetic prophylaxis not reported in the paper but reported in the online protocol (Bai 2011) Conclusion: TIVA with propofol reduced incidence and severity of PONV compared with desflurane in patients with low risk of PONV after RALRP until 6 hours after surgery Letter asking for further information on this study sent 2015 September 16. No reply Funding: faculty research grant of Yonsei University College of Medicine for 2007 (6‐2007‐0190) Conflict of Interest: none
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Computer‐generated random numbers
Allocation concealment (selection bias)	Low risk	A physician outside the trial performed randomization and assignment
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	Participants presumed blinded
Blinding of outcome assessment (detection bias) All outcomes	Low risk	Outcome assessor blinded
Incomplete outcome data (attrition bias) All outcomes	Low risk	No dropout of participants
Selective reporting (reporting bias)	Low risk	All predefined outcomes reported
Other bias	Unclear risk	A third arm with patients treated with TIVA without antiemetic prophylaxis not reported in the paper but reported in the online protocol