Roh 2014.

Methods	Single‐centre, 2‐arm RCT, blinding (participant, caregiver, investigator, outcome assessor)
Participants	Males between 20 and 70 years undergoing robotic assisted laparoscopic radical prostatectomy under general anaesthesia Excluded: chronic renal failure; allergy to propofol, nuts or diuretics; vitamin C or E within 5 days before surgery; BMI > 30 kg/m2; inability to read consent form Estimated enrolment: 50 participants
Interventions	Anaesthesia with desflurane as primary anaesthetics guided by Bispectral Index Score (BIS) vs propofol infusion with target‐controlled infusion (TCI) device guided by BIS
Outcomes	Changes in serum malondialdehyde, interleukin‐1β, interleukin‐6, tumour necrotic factor, nitric oxide during operation (100 minutes after pneumoperitoneum, 10 minutes after decompression) Kidney function after anaesthesia (1 day after surgery) ‐ creatine measure
Notes	Funding: not stated Conflict of interest: not stated

BIS: Bispectral Index Score; BMI: body mass index; RCT: randomized controlled trial; TCI: target‐controlled infusion; TIVA: total intravenous anaesthesia.