Table 2. List of CNVRs significantly associated with MY, FP, FY and PP traits.
| N° | Chr | Start | End | Length | IND | Genes | MY | FP | FY | PP | QTL |
|---|---|---|---|---|---|---|---|---|---|---|---|
| CNVR_1 | 6 | 98915609 | 99081950 | 166342 | 2 | CDS1 | 6.748E-11 | 0.000229 | 0.0006981 | QTL:14011 Milk | |
| CNVR_2 | 7 | 3206482 | 3429935 | 223454 | 4 | 7.99E-06 | |||||
| CNVR_3 | 7 | 18487054 | 18787472 | 300419 | 2 | MYO9A, LOC105615633, LOC105615632, SENP8, GRAMD2, LOC101110145 | 0.0008319 | ||||
| CNVR_4 | 7 | 22026509 | 22172957 | 146449 | 2 | LOC101106264, LOC101106528, LOC105613077, LOC105613076, LOC105613075 | 0.0008319 | ||||
| CNVR_5 | 9 | 78451353 | 78529564 | 78212 | 7 | 0.0002436 | QTL:16015 Milk Fat Yield | ||||
| CNVR_6 | 13 | 19401523 | 20051589 | 650067 | 2 | MALRD1 | 6.051E-07 | ||||
| CNVR_7 | 13 | 20379081 | 20547863 | 168783 | 2 | PLXDC2, LOC105616667 | 6.051E-07 | 1.89E-08 | |||
| CNVR_8 | 13 | 32965686 | 33058560 | 92875 | 2 | ZEB1 | 1.89E-08 | QTL:57750 Milk Protein | |||
| CNVR_9 | 13 | 48832966 | 49706045 | 873080 | 27 | LOC101117953, LOC101118207, LOC101110166 | 6.051E-07 | ||||
| CNVR_10 | 13 | 49006951 | 49706045 | 699095 | 41 | LOC101117953, LOC101118207, LOC101110166 | 6.051E-07 | ||||
| CNVR_11 | 13 | 62376369 | 62539468 | 163100 | 2 | LOC105606911, CBFA2T2, LOC101117009 | 8.93E-05 | ||||
| CNVR_12 | 14 | 14964181 | 15944658 | 980478 | 66 | NETO2, TRNAM-CAU, ITFG1, LOC105613342, PHKB, LOC101110611, LOC105613638, LOC105602056, LOC105602057, LOC105608343 | 9.693E-09 | QTL:57692 Milk Fat Yield | |||
| CNVR_13 | 14 | 14964181 | 15916620 | 952440 | 5 | NETO2, TRNAM-CAU, ITFG1, LOC105613342, PHKB, LOC101110611, LOC105613638, LOC105602056, LOC105602057, LOC105608343 | 9.693E-09 | 2.57E-05 | QTL:57692 Milk Fat Yield | ||
| CNVR_14 | 14 | 15008939 | 15700496 | 691558 | 13 | NETO2, TRNAM-CAU, ITFG1, LOC105613342, PHKB, LOC101110611, LOC105613638, LOC105602056, LOC105602057, LOC105608343 | 9.693E-09 | QTL:57692 Milk Fat Yield | |||
| CNVR_15 | 14 | 17982653 | 18259322 | 276670 | 11 | HEATR3, PAPD5, LOC105616847, ADCY7, BRD7 | 9.693E-09 | ||||
| CNVR_16 | 14 | 43271417 | 43445098 | 173682 | 3 | CHST8 | 2.57E-05 | QTL:160872 Somatic Cell Score | |||
| CNVR_17 | 14 | 44947626 | 46765514 | 1817889 | 2 | FXYD3, LGI4, FXYD1, FXYD7, FXYD5, LOC101123657, LOC101102084, LSR, USF2, HAMP, MAG, LOC105607576, LOC105602063, CD22, FFAR1, FFAR3, LOC101103344, FFAR2, LOC105607577, KRTDAP, DMKN, SBSN, GAPDHS, TMEM147, ATP4A, LOC101108333, LOC105607579, LOC105607578, LOC101104171, HAUS5, RBM42, ETV2, LOC101121538, TRNAT-UGU, UPK1A, ZBTB32, KMT2B, IGFLR1, U2AF1L4, PSENEN, LIN37, HSPB6, PROSER3, LOC101122717, ARHGAP33, PRODH2, NPHS1, KIRREL2, APLP1, NFKBID, HCST, TYROBP, LRFN3, SDHAF1, SYNE4, ALKBH6, CLIP3, THAP8, WDR62, OVOL3, POLR2I, TBCB, CAPNS1, LOC101121285 | 2.57E-05 | ||||
| CNVR_18 | 14 | 45934555 | 46765514 | 830960 | 2 | ZNF565, ZNF146, ZNF567, TRNAW-CCA, ZNF461, ZNF382, LOC105616880, ZNF529, ZNF260, LOC105616879, ZNF566, LOC101102665, LOC105616881, ZFP14, LOC101106873, ZNF568, ZNF829, LOC105607590, ZNF793, LOC101122971, LOC105607591, ZNF383, LOC101105680, LOC105607592, LOC101107890, ZNF527, ZNF569, TRNAE-UUC, LOC105607593, LOC105616882, ZNF570, ZNF420, LOC105616883, LOC101108155, LOC101108415, LOC101108680, ZNF790, LOC101102169 | 2.57E-05 | ||||
| CNVR_19 | 16 | 41463528 | 41637426 | 173899 | 2 | PDZD2, LOC105602599 | 0.0001281 | ||||
| CNVR_20 | 17 | 57986988 | 58424553 | 437566 | 4 | LOC105602890, LOC105602891, LOC105602892, MED13L | 0.0029188 | QTL:57700 Milk Fat Yield, QTL:14002 Somatic Cell Score | |||
| CNVR_21 | 19 | 16600046 | 17485391 | 885346 | 15 | IRAK2, VHL, LOC105603408, BRK1, FANCD2OS, FANCD2, EMC3, LOC105603409, PRRT3, CRELD1, IL17RC, IL17RE, JAGN1, CIDEC, RPUSD3, LOC101103096, LOC105603411, LOC105603410, ARPC4, TADA3, OGG1, CAMK1, BRPF1, CPNE9, MTMR14, LOC105603412, LHFPL4, SETD5, LOC105603622, LOC105603415, THUMPD3, LOC105603414, LOC105603416, LOC105603417, SRGAP3 | 0.0020466 | ||||
| CNVR_22 | 19 | 33480446 | 34472912 | 992467 | 25 | LOC105603452, LOC105603453, SUCLG2, LOC105603455, LOC105603454, LOC105603458, LOC105603456, KBTBD8 | 0.0020466 | ||||
| CNVR_23 | 19 | 40179873 | 41112452 | 932580 | 41 | FHIT, LOC105603489 | 2.491E-14 | ||||
| CNVR_24 | 19 | 43721683 | 43797484 | 75802 | 8 | DNAH12, LOC105603505, TRNAC-GCA, LOC105603504 | 1.48E-13 | ||||
| CNVR_25 | 19 | 44994104 | 45113902 | 119799 | 7 | ERC2 | 2.05E-09 | ||||
| CNVR_26 | 19 | 46527885 | 46544501 | 16617 | 3 | CACNA2D3 | 2.491E-14 | 1.48E-13 | |||
| CNVR_27 | 23 | 12624271 | 13131785 | 507515 | 131 | LOC101104705, SYT4 | 9.671E-05 | ||||
| CNVR_28 | 23 | 12649375 | 13131785 | 482411 | 22 | LOC101104705, SYT4 | 9.671E-05 | ||||
| CNVR_29 | 23 | 37464041 | 38263780 | 799740 | 2 | EMILIN2, LPIN2, MYOM1, LOC105604463, MRCL3, LOC101105123, LOC105604464, LOC105604465, TGIF1, DLGAP1, LOC105604469, LOC105604468, LOC105604467, LOC105604466 | 9.671E-05 | ||||
| CNVR_30 | 23 | 40785469 | 40920221 | 134753 | 57 | PTPRM, LOC105604482 | 9.671E-05 | ||||
| CNVR_31 | 23 | 47820944 | 48653824 | 832881 | 11 | ZBTB7C, LOC105604508, LOC105604510, LOC105604509, CTIF, LOC105604511, TRNAS-GGA | 9.671E-05 | QTL:13906 Milk Yield, QTL:13907 Milk Fat Yield |
N°: number of CNVR
Chr: number of chromosomes
Start: start position of CNVR in bp
End: end position of CNVR in bp
Length: length of the CNVR in bp
IND: number of individuals carrying theper CNVR
Genes: genes symbols identified within of the CNVRs referred to NCBI (www.ncbi.nlm.nih.gov)
MY: milk yield, FP: milk fat percentage, FY: fat yield, PP: protein percentage; phenotypic traits with p-value<0.01 after FDR corrected
QTL: Quantitative Trait Locus overlapped with CNVRs referred to Sheep QTL database (https://www.animalgenome.org/cgi-bin/QTLdb/OA/index)