Comparison 3. Bypass surgery compared with thrombolysis.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Early postoperative non‐thrombotic complications ‐ by site of intervention	1	237	Odds Ratio (M‐H, Fixed, 95% CI)	0.66 [0.34, 1.31]
1.1 Femoro‐popliteal disease	1	168	Odds Ratio (M‐H, Fixed, 95% CI)	0.84 [0.40, 1.76]
1.2 Ilio‐femoral disease	1	69	Odds Ratio (M‐H, Fixed, 95% CI)	0.19 [0.02, 1.58]
2 Procedural mortality ‐ by site of intervention	1	237	Odds Ratio (M‐H, Fixed, 95% CI)	2.09 [0.67, 6.44]
2.1 Femoro‐popliteal disease	1	168	Odds Ratio (M‐H, Fixed, 95% CI)	2.59 [0.70, 9.55]
2.2 Ilio‐femoral disease	1	69	Odds Ratio (M‐H, Fixed, 95% CI)	1.0 [0.09, 11.64]
3 Amputation ‐ by symptoms at time of intervention	1	236	Odds Ratio (M‐H, Fixed, 95% CI)	0.10 [0.01, 0.80]
3.1 Intermittent claudication	1	80	Odds Ratio (M‐H, Fixed, 95% CI)	0.44 [0.02, 11.12]
3.2 Critical limb ischaemia	1	156	Odds Ratio (M‐H, Fixed, 95% CI)	0.06 [0.00, 1.02]
4 Amputation ‐ by site of intervention	1	237	Odds Ratio (M‐H, Fixed, 95% CI)	0.10 [0.01, 0.72]
4.1 Femoro‐popliteal disease	1	168	Odds Ratio (M‐H, Fixed, 95% CI)	0.05 [0.00, 0.83]
4.2 Ilio‐femoral disease	1	69	Odds Ratio (M‐H, Fixed, 95% CI)	0.65 [0.03, 16.46]
5 Mortality within follow‐up ‐ by symptoms at time of intervention	1	236	Odds Ratio (M‐H, Fixed, 95% CI)	1.56 [0.71, 3.44]
5.1 Intermittent claudication	1	80	Odds Ratio (M‐H, Fixed, 95% CI)	1.02 [0.21, 4.87]
5.2 Critical limb ischaemia	1	156	Odds Ratio (M‐H, Fixed, 95% CI)	1.83 [0.73, 4.56]
6 Mortality within follow‐up ‐ by site of intervention	1	237	Odds Ratio (M‐H, Fixed, 95% CI)	1.45 [0.66, 3.18]
6.1 Femoro‐popliteal disease	1	168	Odds Ratio (M‐H, Fixed, 95% CI)	1.95 [0.80, 4.73]
6.2 Ilio‐femoral disease	1	69	Odds Ratio (M‐H, Fixed, 95% CI)	0.37 [0.04, 3.39]