BEST‐CLI trial.

Trial name or title	Best Endovascular Versus Best Surgical Therapy in Patients With Critical Limb Ischemia
Methods	Allocation: randomised Endpoint classification: efficacy study Intervention model: parallel assignment Masking: open label Primary purpose: treatment
Participants	Individuals with PAD presenting with CLI
Interventions	Open surgical revascularization versus endovascular revascularization
Outcomes	Primary outcome measures: Time to major adverse limb event or death, whichever occurs first Secondary outcome measures: Time to reintervention of the index leg, amputation of the index leg, or death, whichever occurs first Number of reinterventions in the index leg Time to all‐cause mortality Change in VascuQoL score Change in EuroQoL EQ‐5D score Treatment‐associated costs Major adverse cardiovascular events Proportion of subjects with at least one perioperative complication
Starting date	August 2014
Contact information	Angela S Knox, MS, PMP aknox@neriscience.com
Notes	NCT02060630 Sponsors and Collaborators: New England Research Institutes; Brigham and Women's Hospital; Massachusetts General Hospital; Boston Medical Center; National Heart, Lung, and Blood Institute (NHLBI)