Study	Reason for exclusion
Biton 2010	Ineligible population: subjects included had primary generalized epilepsy and not partial seizures
Biton 2013	Inelegible population: subjects included in the study had uncontrolled partial epilepsy and generalised tonic‐clonic seizures.
Brzakovic 2012	Inelegible population: subjects included in the study had uncontrolled partial epilepsy and generalised tonic‐clonic seizures.
Carignani 2004	Published as conference abstract: details of the methods and results are not available.
Carignani 2006	Published as conference abstract: details of the methods and results are not available.
Cramer 2013	Not randomised controlled trial.
French 2012	No randomised controlled trial.
Girolineto 2012	Comparative study among therapeutic equivalents of lamotrigine. Not placebo controlled.
Hammer 2008	Published as conference abstract: details of the methods and results are not available.
Hartung 2012	Inelegible population: subjects included in the study had epilepsy, migraine, pain, psychiatric disorders.
Helmstaedter 2013	Subjects included in the study had all epileptic types. Lacosamide as add‐on for epilepsy and in comparison with lamotrigine and topiramate.
Kang 2012	Inelegible population: subjects included in the study had all epileptic types.
Montouris 2007	Published as conference abstract: details of the methods and results are not available.
Ohtahara 2007	Comparative study of lamotrigine and zonisamide. Not placebo controlled
Sander 1990	Study of institutionalised people with severe epilepsy. Subjects included in the study had all epileptic types.
Semah 2014	No LTG add‐on.
Stolarek 1994	Details of the results are not available.
Tomson 2012	Published as conference abstract: details of the methods and results are not available.
Tomson 2013	Not randomised controlled trial.
Veendrick 2000	Published as conference abstract: details of the methods and results are not available.
Yamamoto 2012	Not randomised controlled trial.

AED: antiepileptic drug