Table 3.
Individual Covariate Analysis
| 1-Compartment Model (N = 261) | OFV (change from base model) | |
| CL = (WT/70) ^ 0.75; VD = WT/70 | 2721.201 | |
| Clearance (change from allometric WT) | ||
| *(SCr/0.4) ^ Θ | 2111.387 (−307.368) | |
| *(CrCL/84) ^ Θ | 1827.299 (−893.902) | |
| * Θ ^ (OPNSTR) | 2411.002 (−7.753) | |
| * Θ ^ (CPB) | 2403.192 (−15.563) | |
| * Θ ^ ((UOP + 1)/293) | 2393.425 (−25.33) | |
| *(1/(1 + (PMA/50) ^ Θ)) | 2305.798 (−112.957) | |
| * Θ ^ (LOG((POD + 0.01)/9)) | 2406.806 (−11.949) | |
| Volume of Distribution (change from allometric WT) | ||
| * Θ ^ ((UOP + 1)/293) | 2414.172 (−4.583) | |
| * Θ ^ (LN((POD + 0.01)/9)) | 2418.754 (−0.001) | |
| *(AGEYRS/1.5) ^ Θ | 2398.898 (−19.857) | |
| * Θ ^ OPNSTR | 2415.669 (−3.086) | |
| * Θ ^ CPB | 2418.735 (−0.02) | |
| * Θ ^ M | 2416.777 (−1.978) | |
Θ, estimate; AGEYRS, age in years; CL, clearance; CPB, cardiopulmonary bypass; CrCL, creatinine clearance; LN, natural log; M, male; OFV, objective function value; OPNSTR, open sternum; PMA, postmenstrual age (wk); POD, postoperative day; SCr, serum creatinine (mg/dL); UOP, urine output over the previous 12 hours (mL); VD, volume of distribution; WT, weight (kg)