Table 6.

Simulation of Vancomycin Dosing

Simulation (n = 10000)	Dose, mg/kg/dose	Schedule	Area Under the Curve, mg × L/hr	Attainment of AUC0–24: MIC > 400, %	Serum Concentration, mg/L (%)
Total cohort	10	every 6 hr	377 ± 66	33.2	9.9 ± 2.2 (98.8)
	15	every 8 hr	425 ± 75	60.0	9.7 ± 2.5 (98.2)
	15	every 6 hr	565 ± 98	97.2	14.8 ± 3.2 (53.2)
	20	every 8 hr	565 ± 99	96.9	12.9 ± 3.2 (74.4)
	20	every 12 hr	378 ± 66	33.9	7.0 ± 2.5 (99.8)

MIC, minimum inhibitory concentration