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Big endothelin-1 (inactive precursor peptide) is cleaved by endothelin converting enzyme (ECE) to form Endothelin-1 (ET-1). Endothelin receptors ETA and ETB are expressed on vascular smooth muscle cells (SMC) and mediate vasoconstriction. ETB is also expressed on endothelial cells (EC) where its activation can result in vasodilation mediated by nitric oxide (NO) and prostacyclin (PGI2) release.
