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. Author manuscript; available in PMC: 2020 May 1.
Published in final edited form as: Biochim Biophys Acta Mol Basis Dis. 2018 Sep 3;1865(5):1031–1039. doi: 10.1016/j.bbadis.2018.08.037

Figure 2. Mechanisms of Carbon Tetrachloride Hepatotoxicity.

Figure 2.

Carbon tetrachloride (CCl4) is converted to a radical (CCl3·) that binds to proteins, DNA and lipids. This causes mitochondrial damage and oxidative stress. CCl3· can also react with O2 to form CCl3OO·, which initiates the lipid peroxidation (LPO) chain reaction that damages cell membranes.