. Author manuscript; available in PMC: 2020 May 1.

Published in final edited form as: Biochim Biophys Acta Mol Basis Dis. 2018 Sep 3;1865(5):1031–1039. doi: 10.1016/j.bbadis.2018.08.037

Table 2.

Major animal models of intrinsic drug-induced liver injury

Drug	Favored Species	Typical Dose	Strengths	Weaknesses
Acetaminophen	Mouse	200-600 mg/kg	Easy to use, clinically relevant	Potential interference with metabolism
CCl₄	Rat, Mouse	1-2 mL/kg (10-20 mmol/kg)	Easy to use, can also model chronic DILI	Limited clinical relevance; potential interference with metabolism
Thioacetamide	Mouse, Rat	100-300 mg/kg	Easy to use	Limited clinical relevance; potential interference with metabolism
Furosemide	Mouse	200-500 mg/kg	Easy to use	Limited clinical relevance; potential interference with metabolism
Bromobenzene	Mouse, Rat	0.5-1 mL/kg (5-10 mmol/kg)	Easy to use	Limited clinical relevance; potential interference with metabolism
Allyl alcohol	Mouse, Rat	30-100 mg/kg	Easy to use	Limited clinical relevance; potential interference with metabolism