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Major animal models of idiosyncratic drug-induced liver injury
| Model | Strategy | Strengths | Weaknesses |
|---|---|---|---|
| Inflammagen model | LPS co-administration | Easy to use | Poor resemblance to human IDILI |
| Uetrecht-Pohl model | Compromised immune tolerance | Time course and pathology resemble human IDILI | No liver failure |
| Subclinical mitochondriopathy | Compromised ROS defense | Time course resembles human IDILI | Poor reproducibility |
