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. 2019 Feb 21;4(4):e124952. doi: 10.1172/jci.insight.124952

Figure 5. SGLT2 inhibitor ameliorates age-dependent muscle atrophy in Akita mice.

Figure 5

(A and B) Blood glucose (A; n = 8) and plasma insulin (B; n = 4) levels of WT or Akita mice fed a normal diet (ND) or a diet containing empagliflozin (Empa) beginning at 5 weeks of age. (C–E) Skeletal muscle/body mass ratios (C; n = 8) as well as histological determination of muscle fiber area in tibialis anterior muscle (D and E) of mice as in A at 10 weeks of age. In E, the areas of 200 fibers were measured in each condition. All quantitative data are means ± SEM for the indicated numbers of mice. *P < 0.05, **P < 0.01 for Akita Empa versus Akita ND (A) or for the indicated comparisons. NS, not significant. Two-way ANOVA with Bonferroni’s post hoc test (A–C, and E).