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. 2019 Feb 21;4(4):e126444. doi: 10.1172/jci.insight.126444

Figure 5. Afatinib amplifies forskolin-induced current in T84 cells.

Figure 5

(A) (Left) short-circuit current in T84 cells in response to 20 μM afatinib (or vehicle control) followed by indicated concentrations of forskolin, then 10 μM BPO-27. (Right) forskolin concentration dependence of short-circuit current (mean ± SEM, n = 6). (B) (Left) short-circuit current in T84 cells in response to additions of EBIO (500 μM) and/or afatinib (20 μM) added 25 minutes before 100 μM carbachol followed by 10 μM forksolin. (Right) summary of peak carbachol- and forskolin-induced currents (mean ± SEM, n = 3–5). *P < 0.05, by 2-tailed t test.