Figure 6. K⁺ channel inhibitors block the afatinib-induced augmentation in carbachol current.

(Left) short-circuit current in T84 cells treated with 20 μM afatinib, 30 μM clotrimazole, and/or 10 μM senicapoc, as indicated, 30 minutes before addition of 100 μM carbachol followed by 10 μM forskolin. (Right) summary of peak carbachol- and foskolin-induced peak current (mean ± SEM, n = 3–4; *P < 0.05, by 2-tailed t test).