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. 2019 Feb 21;4(4):e122043. doi: 10.1172/jci.insight.122043

Figure 1. AXT107 potentiates the activation of Tie2 by Ang2.

Figure 1

(A and B) Representative Western blots of MEC lysates treated with 200 ng/ml Ang1 (n = 6–8) (A) or 200 ng/ml Ang2 (n = 3) (B) and 0–100 μM AXT107 showing phosphorylation of Tie2 (Y992) and downstream effectors Akt (S473) and ERK1/2 (T202/Y204), with GAPDH as a loading control. (C and D) Densitometric analysis of Western blots described in A (C) and B (D) adjusted for loading control and presented relative to Ang1- or Ang2-alone control. *P < 0.05, ***P < 0.001 by 1-way ANOVA relative to Ang1- or Ang2-alone control.