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. Author manuscript; available in PMC: 2019 Apr 23.
Published in final edited form as: Cancer Immunol Res. 2017 Dec 20;6(2):151–162. doi: 10.1158/2326-6066.CIR-17-0114

Figure 1. Elements of ImmunoMap Algorithm.

Figure 1.

A) Weighted Repertoire Dendogram visualize relatedness of sequences within repertoire along with relative frequency of CDR3 amino acid sequences. B) Dominant Motif Analysis clusters homologous sequences and selects for clusters contributing to significant proportion of the response. 3 Dominant Motifs are shown representing highly represented structural motifs in this individual’s CMV response. C) Singular Clone Analysis defines sequences that expand significantly over the summation of all other homologous sequences D) Novel Clone Analysis is implemented when comparing repertoires from different samples and a novel clone is defined as one that expands significantly over the summation of all homologous sequences in the other sample.