Table 4.
Modified Jadad scores of the four included studies
| SAVE28 2013 | Ibrahim et al21 | SAVE 229 2016 | SAKURA27 2016 | |
|---|---|---|---|---|
| “Was the study described as randomized?” | Y | Y | Y | Y |
| “Was the randomization protocol detailed and appropriate?” | Y | Y | Y | Y |
| “Was the study described as double-blind?” | N | N | N | Y |
| “Was the blinding process detailed and appropriate?” | N | N | N | Y |
| “Did the study have a control group?” | Y | Y | Y | Y |
| “Was the control detailed and appropriate?” | N | N | Y | Y |
| “Was there an adequate exclusion criterion?” | Y | Y | Y | Y |
| “Was the intervention used at a therapeutic dose?” | Y | Y | Y | Y |
| “Was there a description of withdrawals and dropouts?” | Y | Y | Y | Y |
| “Were the data clearly and adequately reported?” | Y | Y | Y | Y |
| Score (total =10) | 7 | 7 | 8 | 10 |
Note: Ibrahim et al21 is a follow-up study of the SAVE trial.
Abbreviation: RCT, randomized controlled trial.