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. Author manuscript; available in PMC: 2020 May 1.
Published in final edited form as: Kidney Int. 2019 Mar 4;95(5):1253–1261. doi: 10.1016/j.kint.2018.12.023

Fig. 5.

Fig. 5.

Effect of gene type and test of mediation model. A. Trajectories of GFR estimated from modeling the entire CRISP cohort, using gene type as a predictor variable (Model 1 in Table 3). B. Diagram of unmediated model. C. Diagram of mediated model. X, causal variable; Y, outcome variable; M, mediator variable. Path a represents the association between X and M, and path b the association between M and Y. Path c represents the association between X and Y (total effect), and path c’ represents the association between X and Y after controlling for M (direct effect). The effect mediated by Irazabal class (c-c’), is called the indirect effect and is equal to the product of the coefficients, ab.