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. Author manuscript; available in PMC: 2020 May 1.
Published in final edited form as: Kidney Int. 2019 Mar 4;95(5):1253–1261. doi: 10.1016/j.kint.2018.12.023

Table 3.

Effect of gene type on GFR in polynomial models with and without adjustment for Irazabal class

Variable Model 1 Model 2
Coefficient 95% CI P value Coefficient 95% CI P value
Age 2.08 1.02, 3.14 <0.001 5.27 4.05, 6.49 <0.001
Age2 −0.0466 −0.0590, −0.0342 <0.001 −0.0618 −0.0741, −0.0495 <0.001
Gene 40.6 20.6, 60.7 <0.001 25.3 5.77, 44.9 0.011
Gene × age −1.44 −1.92, −0.96 <0.001 −0.61 −1.08, −0.13 0.012
Class 19.4 12.5, 26.3 <0.001
Class × age −0.89 −1.07, −0.71 <0.001
Intercept 87.7 62.2, 113.1 <0.001 20.0 −11.8, 51.9 0.218

Outcome is measured GFR in mL/min/1.73 m2

Age is in years

Gene, gene type: PKD1 vs. PKD2 or NMD

Class, Irazabal class: 1A through 1E, coded as 1-5, respectively