Table 2.

Transferability analysis of established BMI SNPs with maximum BMI in adulthood, maximum BMI recorded at a non-diabetic exam, and maximum BMI z-score in childhood in longitudinally studied full-heritage Pima Indians

Lead SNP	Locus (in/nearest)	Allele R/N	Full-heritage Pima Indians								Reported Meta-Analysis GIANT			Heterogeneity
			Maximum BMI Adulthood(n=3491)				Maximum BMI (Non-diabetic) Adulthood(n=2862)		Maximum Z-score Childhood(n=1958)		BMIAdulthood (n=339224)
			RAF	Beta (SD)	Beta (Loge)	P	Beta (Loge)	P	Beta (SD)	P	RAF	Beta (SD)	P	I2(%)	Phet
rs2867125	TMEM18	C/T	0.86	0.13	0.030	3.0×10−4	0.035	6.0×10−5	0.131	0.005	0.87	0.06	4.4 ×10−52	75.2	0.045
rs7903146	TCF7L2	C/T	0.92	0.16	0.039	4.9×10−4	0.051	2.0×10−5	0.088	0.18	0.75	0.02	1.1×10−12	87.6	0.004
rs13041126	MRPS33P4	T/C	0.67	0.08	0.018	0.004	0.019	0.006	0.051	0.16	0.73	0.02	6.5×10−7	78.6	0.031
rs12885454	PRKD1	C/A	0.78	0.09	0.020	0.005	0.016	0.04	0.066	0.11	0.63	0.02	9.1×10−11	78.2	0.032
rs6091540	ZFP64	C/T	0.67	0.07	0.016	0.01	0.017	0.01	0.033	0.36	0.73	0.02	2.1×10−8	70.3	0.066
rs7193144	FTO	C/T	0.14	0.10	0.022	0.01	0.029	0.002	0.14	0.003	0.44	0.08	6.2×10−142	0.0	0.686
rs977747	TAL1	T/G	0.74	0.08	0.017	0.02	0.021	0.004	0.061	0.13	0.47	0.02	2.2×10−8	75.2	0.044
rs9641123*	CALCR	C/G	0.09	0.11	0.023	0.02	0.021	0.05	0.059	0.32	0.39	0.01	1.8×10−7	79.2	0.028
rs10938397	GNPDA2	G/A	0.31	0.06	0.014	0.02	0.014	0.05	0.096	0.009	0.43	0.03	1.4×10−40	27.6	0.240
rs17203016	CREB1	G/A	0.15	0.08	0.017	0.03	0.016	0.06	0.073	0.12	0.20	0.02	3.4×10−8	59.2	0.117
rs10733682	LMX1B	A/G	0.75	0.06	0.014	0.04	0.017	0.02	0.056	0.15	0.43	0.02	2.5×10−10	41.1	0.192
rs2531995	ADCY9	T/C	0.18	0.07	0.016	0.04	0.010	0.21	0.082	0.06	0.59	0.02	7.6×10−10	53.5	0.142
rs758747	NLRC3	T/C	0.11	0.07	0.018	0.05	0.014	0.14	0.074	0.15	0.27	0.02	1.5×10−10	37.7	0.205
rs1460676*	FIGN	C/T	0.07	0.08	0.018	0.11	0.018	0.16	0.143	0.03	0.22	0.02	5.0×10−8	22.2	0.257
rs9374842*	LOC285762	T/C	0.86	0.02	0.003	0.68	0.011	0.23	0.139	0.005	0.74	0.01	7.2×10−9	0.0	0.749
rs1441264*	MIR548A2	A/G	0.73	0.01	0.002	0.78	0.003	0.62	0.114	0.003	0.55	0.01	3.0×10−8	0.0	0.933
rs1555543	PTBP2	C/A	0.54	−0.01	−0.001	0.93	−0.001	0.89	0.076	0.03	0.57	0.02	5.5×10−11	0.0	0.336

Data are only given for the SNPs associated with maximum BMI in adulthood and/or maximum BMI z-score in childhood with p≤0.05 in full-heritage Pima Indians (n as indicated). R: risk allele; N: non-risk allele; RAF: risk allele frequency. The risk allele is defined as the allele with higher risk for BMI in Europeans. Beta and p value are adjusted for age, sex, birth year and the first five genetic principal components. BMI is log_e-transformed before analyses to approximate a normal distribution. Data for meta-analysis of GIANT in Europeans are derived from the public database and beta coefficients are expressed in SD units by inverse Gaussian transformation of BMI. For comparison with beta coefficients in Europeans, maximum BMI in Pima Indians is also transformed using an inverse Gaussian transformation; results are presented as beta (SD) and used in heterogeneity analyses. I² represents the percentage of variance in the effect attributable to heterogeneity between Pima Indians and Europeans, and P_het is the p value for the null hypothesis that the two betas are equal.

^*A proxy SNP was used for genotyping (listed in Table S1). Bold values: p ≤ 0.05.