. Author manuscript; available in PMC: 2019 Sep 18.

Published in final edited form as: Obesity (Silver Spring). 2019 Mar 18;27(5):845–854. doi: 10.1002/oby.22433

Table 3.

Associations of additional SNPs with BMI in 98 established BMI loci in an expanded population-based study of American Indians

Locus	SNP				Maximum BMI Full-heritage (n=3491)		Maximum BMI Mixed-heritage (n=3298)		Maximum BMI Combined (n=6789)		BMI GIANT (n=339224)
Locus	RS#	Allele 1/2	Freq Alelle1 American Indian	Freq Allele1 European	Beta (Log_e)	P	Beta (Log_e)	P	Beta (Log_e)	P	Beta (SD)	P
NLRC3	rs3751837	T/C	0.11	0.22	0.023	0.02	0.028	0.002	0.028	5.8×10⁻⁵	-	-
NLRC3	rs11646156	C/G	0.06	0.03	0.025	0.05	0.025	0.04	0.029	0.001	0.028	0.003
NLRC3	rs758747	T/C	0.13	0.27	0.018	0.05	0.019	0.03	0.019	0.004	0.023	1.5×10⁻¹⁰
PGPEP1	rs12462812	A/G	0.19	0.01	−0.016	0.03	−0.022	0.007	−0.019	0.0005	-	-
ADCY9	rs2531982	A/G	0.86	0.70	−0.023	0.01	−0.022	0.01	−0.022	0.0005	−0.020	5.0×10⁻⁷
ADCY9	rs2531995	T/C	0.21	0.59	0.016	0.04	0.017	0.02	0.017	0.002	0.024	7.6×10⁻¹⁰
ADCY9	rs35384844	T/C	0.86	0.95	−0.017	0.04	−0.020	0.02	−0.018	0.004	-	-
CADM1	rs149906922	A/T	0.38	0	0.019	0.001	0.014	0.03	0.016	0.0007	-	-
CADM1	rs718484	A/G	0.28	0.09	0.019	0.003	0.020	0.005	0.016	0.001	0.007	0.29
CADM1	rs77550241	A/G	0.25	0.01	0.018	0.008	0.020	0.007	0.015	0.003	-	-
CADM1	rs17118342	T/C	0.78	1	−0.020	0.005	−0.017	0.03	−0.014	0.007	-	-
CADM1	rs11215485	T/C	0.30	0.12	0.019	0.003	0.013	0.05	0.013	0.008	−0.001	0.85
CADM1	rs72306674	−/TCTC	0.25	0.01	0.016	0.01	0.017	0.02	0.013	0.01	-	-
LRP1B	rs17602834	T/C	0.60	0.48	−0.013	0.04	−0.015	0.02	−0.015	0.0009	0.007	0.10
LRP1B	rs17576955	A/G	0.91	0.99	0.023	0.02	0.022	0.03	0.021	0.005	0.012	0.32
ZFP64	rs139447701	A/C	0.18	0	−0.019	0.008	−0.016	0.05	−0.019	0.001	-	-
ZFP64	rs6021702	T/C	0.17	0.37	0.022	0.02	0.016	0.04	0.017	0.005	−0.003	0.56
ZFP64	rs11086366	A/C	0.54	0.88	0.012	0.05	0.016	0.01	0.013	0.005	0.001	0.88
FTO	rs1861869	C/G	0.70	0.47	−0.013	0.04	−0.015	0.02	−0.015	0.001	−0.030	9.9×10⁻¹⁷
FTO	rs3751814	A/G	0.15	0.41	0.021	0.009	0.017	0.05	0.019	0.002	-	-
FTO	rs7206790	C/G	0.81	0.49	−0.019	0.01	−0.016	0.04	−0.017	0.002	−0.066	3×10⁻⁹⁵
TCF7L2	rs146479796	T/C	0.80	1	−0.017	0.02	−0.017	0.03	−0.017	0.002	-	-
TCF7L2	rs7895657	A/G	0.29	0.30	0.013	0.05	0.013	0.05	0.012	0.01	-	-
ZBTB10	rs183925020	A/C	0.13	0	0.019	0.02	0.021	0.04	0.021	0.002	-	-
ZBTB10	rs575452	A/G	0.75	0.87	0.020	0.003	0.014	0.05	0.015	0.004	0.000	0.95
RARB	rs186133817	C/G	0.75	0.87	−0.016	0.01	−0.015	0.04	−0.016	0.002	-	-
CLIP1	rs34383196	T/C	0.29	0.24	0.013	0.04	0.018	0.01	0.015	0.002	-	-
LMX1B	rs3814120	A/G	0.30	0.07	0.015	0.02	0.014	0.03	0.015	0.002	0.022	0.0008
LMX1B	rs10733682	A/G	0.75	0.43	0.014	0.04	0.019	0.01	0.016	0.003	0.019	2.5×10⁻¹⁰
LMX1B	rs16929203	T/C	0.32	0.08	0.016	0.01	0.013	0.05	0.014	0.003	0.022	0.0006
LMX1B	rs28687510	T/G	0.32	0.11	0.015	0.01	0.013	0.05	0.014	0.004	-	-
LMX1B	rs10739682	T/C	0.89	0.63	0.023	0.03	0.018	0.05	0.018	0.01	-	-
LOC284260	rs9304270	T/C	0.12	0.10	0.018	0.04	0.022	0.02	0.020	0.003	0.001	0.89
GPRC5B	rs1292635	A/G	0.10	0.23	0.020	0.05	0.021	0.04	0.021	0.005	−0.001	0.82
MC4R	rs1943217	T/G	0.47	0.71	−0.013	0.03	−0.013	0.03	−0.012	0.005	−0.011	0.05
MC4R	rs8092350	A/C	0.55	0.66	−0.012	0.04	−0.012	0.04	−0.011	0.01	−0.032	1.3×10⁻²²
CALCR	rs12666730	T/C	0.49	0.86	0.012	0.05	0.014	0.02	0.012	0.008	0.006	0.19
EHBP1	rs147306320	T/C	0.08	0	−0.020	0.04	−0.027	0.03	−0.018	0.03	-	-

Data are given for the analysis of full-heritage Pima Indians, mixed-heritage Pima Indians and combined samples (n as indicated). Allele 1 is defined as the reference allele; allele 2 is as the altered allele. Beta and p value are adjusted for age, sex, birth year and the first five genetic principal components. SNPs which were not available in the meta-analysis of GIANT are denoted with “-“.