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. 2018 Oct 23;25(11):3077–3090. doi: 10.1038/s41380-018-0282-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Extended structure of Family 66494 that links seven suicides (shaded in black) used for Shared Genomic Segment (SGS) analyses. Suicide cases are not as evident in upper generations because suicide status from death certificates is only available back to 1904. Note that gender is disguised and sibship order is randomized in order to protect the privacy of family members. Family size: there are 34 total meioses between the seven cases in this family; this counting is shown in purple on the drawing. SGS requires a total of at least 15 meioses between cases for adequate statistical power. Shared segments: three genomic segments provided significant evidence of sharing between cases in this family. The pattern of segregation of each segment is shown. Cases 2, 4, 5, 6, and 7 share region 1 (red). Cases 1, 2, 3, 4, 5, and 6 share region 2 (gold). Cases 1, 2, 3, 4, and 7 share region 3 (blue). Essential segregation is shown; however, when cases do not share, the region can actually be lost at any meiosis above the case in the family tree. The exact point of this loss is unknown