Table 3.
Genes in significant SGS regions with supporting evidence of association with suicide
| Ensembl ID | Chr | Start | End | Gene name | Suicide associations; other neuropsychiatric associationsa | Inflammation/immune associations | Families | Type of Sequence within region |
|---|---|---|---|---|---|---|---|---|
| ENSG00000162670 | 1 | 190066792 | 190446759 | BRINP3 | GWAS suicidal behavior [38]; smoking cessation | Peri-implantitis [39] and ulcerative colitis [40] | 791533, 504775 | Regulatory |
| ENSG00000150681 | 1 | 192127587 | 192154945 | RGS18 | GWAS suicidality in MDD [41]; anorexia; neuroticism | Controls platelet function [42] | 791533, 504775 | Regulatory |
| ENSG00000151689 | 2 | 191208196 | 191236391 | INPP1 | Candidate gene study in suicide attempts in patients with BD [43]; lithium response; autism; neurodevelopment | Systemic lupus erythematosus and Sjögren’s syndrome [44] | 176860, 11593 | Coding |
| ENSG00000115419 | 2 | 191745553 | 191830278 | GLS | Decreased PM brain tissue gene expression, suicide, and depression [45]; glutamate synthesis; schizophrenia | Immune function [46] | 176860, 11593 | Coding |
| ENSG00000115415 | 2 | 191829084 | 191885686 | STAT1 | Increased gene expression in PM brain tissue of suicides [47]; dementia; Alzhimer’s | Autoinflammatory disorder [48], vascular inflammation [49], and autoimmune disorders [50, 51] | 176860, 11593 | Coding |
| ENSG00000164867 | 7 | 150688083 | 150711676 | NOS3 | Candidate gene study, suicide attempt, and aggression [52]; bipolar; major depression; schizophrenia | Asthma, inflammatory bowel disease, and arthritis [53] | 957634, 595955 | Coding |
| ENSG00000164885 | 7 | 150750899 | 150755617 | CDK5 | Gene expression, completed suicide [54]; autism; Alzheimer’s | Neuroinflammation [55] | 957634, 595955 | Coding |
| ENSG00000146926 | 7 | 150872785 | 150884919 | ASB10 | MDD and completed suicide [56] | Systemic sclerosis [57] | 957634, 595955 | Coding |
| ENSG00000013374 | 7 | 151038785 | 151075535 | NUB1 | Increased expression in peripheral blood of suicides with BD [58]; Parkinson’s | None known | 957634, 595955 | Coding |
| ENSG00000106615 | 7 | 151163098 | 151217206 | RHEB | GWAS of antidepressant-emergent suicidal ideation [59]; pain threshold | Allergic asthma [60] | 957634, 595955 | Coding |
| ENSG00000106617 | 7 | 151253197 | 151574210 | PRKAG2 | MDD and completed suicide [56]; schizophrenia | Chronic inflammatory skin disease [61] | 957634, 595955 | Coding |
| ENSG00000026025 | 10 | 17270258 | 17279592 | VIM | Increased PM brain tissue gene expression in suicides [62]; anorexia; bulimia; Alzheimer’s | Rheumatoid arthritis [63] | 11593, 8556 | Regulatory |
| ENSG00000183230 | 10 | 67672276 | 69455927 | CTNNA3 | GWAS of antidepressant-emergent suicidal ideation [59]; bipolar; major depression; Alzheimer’s; schizophrenia | Asthma [64] | 27251, 233769 | Coding |
| ENSG00000110092 | 11 | 69455855 | 69469242 | CCND1 | Decreased gene expression in veterans with suicide attempts [65]; major depression | Rheumatoid arthritis [66] | 540775 | Regulatory |
| ENSG00000151233 | 12 | 42475647 | 42538681 | GXYLT1 | Sequence study, MDD, and completed suicide [56] | None known | 209487, 66494 | Regulatory |
| ENSG00000102468 | 13 | 47405685 | 47471169 | HTR2A | Candidate gene, gene expression, studies of suicidal behavior [67–74]; affective disorders; alcoholism; Alzheimer’s; anxiety; bipolar; eating disorders; pain; psychosis; schizophrenia; Tourette syndrome | Regulation of immune response [75] | 27251, 41469 | Regulatory |
| ENSG00000027075 | 14 | 61909885 | 62016549 | PRKCH | Increased gene expression in veterans with suicide attempts [65]; major depression | Rheumatoid arthritis [76] | 590241, 601627 | Coding |
| ENSG00000128923 | 15 | 59063391 | 59154099 | MINDY2 (FAM63B) | Meta-analysis of three suicide cohorts [58]; cognition in schizophrenia | None known | 709 | Coding |
aBroad evidence for additional neuropsychatric disease associations were obtained from a search of the HuGE Literature Finder, part of the Centers for Disease Control and Prevention Public Health Genomics Knowledge Base (v3.1; https://phgkb.cdc.gov/PHGKB/)