Table 2.

Bronchoalveolar lavage inflammation in BALB/c mice 24 hours after the challenge with 0.3, 0.5 or 1 mg/kg of LPS.

	PBS (50 μl)	LPS (0.3 mg/kg)	LPS (0.5 mg/kg)	LPS (1 mg/kg)
Neutrophils (× 105 cells/ml)	0.66 ± 0.21	9.9 ± 1.1*	10.1 ± 0.8*	11.6 ± 2.4*
Macrophages (× 105 cells/ml)	1.65 ± 0.23	1.24 ± 0.4	1.43 ± 0.07	1.69 ± 0.21
Lymphocytes (× 105 cells/ml)	0.02 ± 0.01	0.10 ± 0.02*	0.06 ± 0.01*	0.10 ± 0.07*
Total cell counts (× 105 cells/ml)	2.34 ± 0.29	10.29 ± 1.09*	11.6 ± 0.8*	13.4 ± 2.6*
MPO (mU/ml)	41.2 ± 0.007	1045.5 ± 178.6*	1451.7 ± 123.4*	1235.8 ± 368.7*
Elastase (ng/ml)	0 ± 0	264.4 ± 21.9*	215.8 ± 8.5*	287.5 ± 21.4*

Animals were intranasally challenged with 0.3, 0.5 or 1 mg/kg of LPS or PBS alone (50 μl). Twenty four hours after the challenge, animals were sacrificed and bronchoalveolar lavage performed. Data are expressed as mean ± SEM 6 mice per group. Significance, (P < 0.05) indicated by (*) is versus PBS-challenged mice.