Table 3.
Relationship between hypoxia-inducible factor 1α and clinicopathological factors in patients with gastric cancer
| Characteristics | Sample size, n |
HIF1α |
P | |
| Low expression (%) | High expression (%) | |||
| Gender | 93 (66.4) | 47 (33.6) | ||
| Male | 112 | 76 (67.9) | 36 (32.1) | 0.474 |
| Female | 28 | 17 (60.7) | 11 (39.3) | |
| Age | ||||
| < 60 yr | 67 | 47 (70.1) | 20 (29.9) | 0.372 |
| ≥ 60 yr | 73 | 46 (63.0) | 27 (37.0) | |
| Tumor location | ||||
| Upper part | 57 | 41 (71.9) | 16 (28.1) | 0.702 |
| Middle part | 34 | 19 (55.9) | 15 (44.1) | |
| Lower part | 44 | 30 (68.2) | 14 (31.8) | |
| Total stomach | 5 | 3 (60.0) | 2 (40.0) | |
| Tumor size | ||||
| < 5 cm | 57 | 41 (71.9) | 16 (28.1) | 0.253 |
| ≥ 5 cm | 83 | 52 (62.7) | 31 (37.3) | |
| Depth of invasion | ||||
| T1 | 5 | 5 (100.0) | 0 (0.0) | 0.001 |
| T2 | 13 | 12 (92.3) | 1 (7.7) | |
| T3 | 85 | 60 (70.6) | 25 (29.4) | |
| T4 | 37 | 16 (43.2) | 21 (56.8) | |
| Lymphatic metastasis | ||||
| 0 | 34 | 29 (85.3) | 5 (14.7) | 0.000 |
| 1-2 | 32 | 24 (75.0) | 8 (25.0) | |
| 3-6 | 31 | 23 (74.2) | 8 (25.8) | |
| 7-15 | 37 | 17 (45.9) | 20 (54.1) | |
| ≥ 16 | 6 | 0 (0.0) | 6 (100.0) | |
| Borrmann classification | ||||
| Type I | 16 | 11 (68.8) | 5 (31.2) | 0.183 |
| Type II or III | 110 | 76 (69.1) | 34 (30.9) | |
| Type IV | 11 | 4 (36.4) | 7 (63.6) | |
| Type V | 3 | 2 (66.7) | 1 (33.3) | |
| WHO histological classification | ||||
| Adenocarcinoma | 77 | 55 (71.4) | 22 (28.6) | 0.725 |
| Signet-ring cell carcinoma | 17 | 12 (70.6) | 5 (29.4) | |
| Mucinous adenocarcinoma | 8 | 6 (75.0) | 2 (25.0) | |
| Mixed carcinoma | 32 | 20 (62.5) | 12 (37.5) | |
| Neuroendocrine carcinoma | 6 | 4 (66.7) | 2 (33.3) | |
| Lauren parting | ||||
| Intestinal type | 65 | 42 (64.6) | 23 (35.4) | 0.155 |
| Diffuse type | 68 | 44 (64.7) | 24 (35.3) | |
| Mixed type | 7 | 7 (100.0) | 0 (0.0) | |
| Differentiation grade | ||||
| Low and middle | 107 | 72 (67.3) | 35 (32.7) | 0.698 |
| High | 33 | 21 (63.6) | 12 (36.4) | |
| Cancer embolus | ||||
| Yes | 51 | 32 (62.7) | 19 (37.3) | 0.485 |
| No | 89 | 61 (68.5) | 28 (31.5) | |
| Affect neural | ||||
| Yes | 50 | 30 (60.0) | 20 (40.0) | 0.230 |
| No | 90 | 63 (70.0) | 27 (30.0) | |
| TNM staging | ||||
| I | 10 | 10 (100.0) | 0 (0.0) | 0.000 |
| II | 49 | 44 (89.8) | 5 (10.2) | |
| III | 81 | 39 (48.1) | 42 (51.9) | |
HIF1α: Hypoxia-inducible factor 1α; WHO: Word Health Organization; TNM: Tumor-node-metastasis.