Table 2.
Associations between variants in locus that are targets of novel drugs for the treatment of nonalcoholic steatohepatitis and multiple traits from individuals of the United Kindom Biobank
| Trait | Variant | Position | -log10(p-value) |
| NR1H4 (FXR) Farnesoid X-Activated Receptor | |||
| K85 Acute pancreatitis | rs76372051 | 100945711 | 6.963890333 |
| Immature reticulocyte fraction | rs35712 | 100971355 | 5.607954097 |
| Impedance of arm (right) | rs1409791 | 100851307 | 5.152661824 |
| Impedance of whole body | rs1409791 | 100851307 | 4.772216099 |
| migraine | rs12579460 | 100966714 | 4.639293011 |
| high cholesterol | rs7967468 | 100853792 | 4.543497322 |
| N30-N39 Other diseases of urinary system | rs79306023 | 100938470 | 4.420628035 |
| H81 Disorders of vestibular function | rs140644635 | 100923359 | 4.069764347 |
| PPARδ (Peroxisome Proliferator Activated Receptor Delta) | |||
| Whole body fat-free mass | rs36018387 | 35386872 | 59.74853212 |
| Hip circumference | rs36018387 | 35386872 | 49.20670564 |
| Whole body fat mass | rs36018387 | 35386872 | 37.00113934 |
| Body fat percentage | rs36018387 | 35386872 | 20.45328464 |
| Monocyte percentage | rs9469982 | 35267548 | 45.86340625 |
| Platelet crit | rs33959228 | 35259397 | 21.6726615 |
| White blood cell (leukocyte) count | rs9380500 | 35266231 | 21.54556677 |
| Platelet count | rs9658111 | 35364534 | 17.88276186 |
| Neutrophill count | rs9380500 | 35266231 | 17.11253462 |
| Eosinophill percentage | rs2395625 | 35405461 | 15.34904201 |
| Lymphocyte percentage | rs9658079 | 35327577 | 9.741626151 |
| asthma | rs1557568 | 35260530 | 9.184130164 |
| K90 Intestinal malabsorption | rs7771474 | 35320447 | 11.86097145 |
| MPC1 (Mitochondrial Pyruvate Carrier 1) | |||
| Mean platelet (thrombocyte) volume | rs10946160 | 166757818 | 7.378512135 |
| Platelet count | rs3728 | 166778679 | 5.285527735 |
| Red blood cell (erythrocyte) count | rs6916128 | 166759313 | 4.825911105 |
| M31 Other necrotising vasculopathies | rs7449594 | 166774429 | 4.699926505 |
| dyspepsia / indigestion | rs6909951 | 166758198 | 4.594790286 |
| MAP3K5 (ASK-1) (Mitogen-Activated Protein Kinase Kinase Kinase 5) | |||
| Mean platelet (thrombocyte) volume | rs6924387 | 137082948 | 14.48853109 |
| Eosinophill count | rs932589 | 137083138 | 13.39556873 |
| Lymphocyte percentage | rs6924387 | 137082948 | 10.84396601 |
| Neutrophill count | rs6924387 | 137082948 | 10.59715422 |
| Platelet count | rs9321570 | 137095679 | 9.792150289 |
| White blood cell (leukocyte) count | rs6924387 | 137082948 | 9.574319083 |
| Eosinophill percentage | rs932589 | 137083138 | 9.344890391 |
| Monocyte count | rs9385775 | 137144920 | 9.1157769 |
| Mean reticulocyte volume | rs9385775 | 137144920 | 8.817927896 |
| Platelet distribution width | rs6924387 | 137082948 | 8.001963098 |
| THRβ (Thyroid Hormone Receptor Beta) | |||
| Mean corpuscular volume | rs869785 | 24347800 | 152.2743497 |
| Mean corpuscular haemoglobin | rs869784 | 24348008 | 143.9371173 |
| Red blood cell (erythrocyte) count | rs869785 | 24347800 | 61.9076303 |
| Mean reticulocyte volume | rs869784 | 24348008 | 43.97976306 |
| Reticulocyte count | rs1505307 | 24343330 | 16.57632823 |
| Immature reticulocyte fraction | rs869784 | 24348008 | 15.67096843 |
| Monocyte count | rs12485694 | 24346109 | 11.11788547 |
| Lymphocyte count | rs13096529 | 24232035 | 10.58643203 |
| Red blood cell (erythrocyte) distribution width | rs2167115 | 24339734 | 10.44361306 |
| C56 Malignant neoplasm of ovary | rs189397255 | 24389732 | 12.2277003 |
| Trunk fat-free mass | rs13100197 | 24491484 | 8.731024419 |
| Trunk predicted mass | rs13100197 | 24491484 | 8.614769205 |
| Leg fat percentage (left) | rs1349265 | 24159387 | 8.323233252 |
The associations have been computed using 452264 United Kindom Biobank White British individuals. http://geneatlas.roslin.ed.ac.uk/.