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. 2019 Apr 17;12:98. doi: 10.3389/fnmol.2019.00098

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Copyright © 2019 Xia, Chen, Wang, Yin, Guo, Li, Li, Tang, Jia, Hu, Liu and Feng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Transient receptor potential ankyrin 1 (TRPA1) blockers improved motor dysfunction and nerve conduction in the ICH mice. (A) TRPA1 was expressed on the myelin. The sham group was assessed on D1 after sham surgery. (B) The extended MEPs latency was restored by TRPA1 blockers, and the left MEPs was detected (n = 3). (C,D) The TRPA1 blockers (HC-030031 and A-967079) increased the basso mouse scale (BMS) and beam balance test scores of the ICH mice (n = 6). (E) The TRPA1 blockers improved muscle strength in the ICH mice (n = 6). Unless specified, scale bars represent 50 μm. The time before white vertical lines represents the long latency of MEPs, and the moment of using electrical stimulation is at the beginning of the trace. Crossbars are the markers of the amplitude of MEPs detected by software (**P < 0.01 vs. sham group, ^#P < 0.05, ^##P < 0.01).