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. 2019 Apr 17;12:98. doi: 10.3389/fnmol.2019.00098

Figure 3.

Figure 3

Changes in the white matter after application of the TRPA1 blockers and agonist to the ICH mice. (A) The TRPA1 blockers significantly enhanced the immunofluorescence intensity of NF200 and MBP on D1 and D3 in the ICH mice (n ≥ 3). (B) MBP expression was increased after application of the TRPA1 blockers. The sham group was assessed on D3 after sham surgery (n ≥ 3). (C) The TRPA1 blockers reduced the immunofluorescence intensity of DMBP on D3 in the ICH mice (n ≥ 3). (D) The TRPA1 agonist aggravated the myelin damage. The sham group was assessed on D3 after sham surgery (n ≥ 3). (E) The thinning and disintegration of myelin were reduced by the TRPA1 blockers. (F) The TRPA1 blocker HC-030031 could reduce axonal oedema. The red arrows mark the phenomenon of demyelination, and the black arrows indicate the reduction of demyelination. Unless specified, scale bars represent 50 μm (*P < 0.05 vs. sham group, **P < 0.01 vs. sham group, #P < 0.05, ##P < 0.01).