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. 2019 Apr 17;12:98. doi: 10.3389/fnmol.2019.00098

Figure 4.

Figure 4

The signal pathway downstream of TRPA1 induced myelin injury. (A) NADPH oxidase 1 (NOX1) and Calpain1 expression were enhanced in the ICH mice. The sham group was assessed on D3 after sham surgery (n ≥ 3). (B,C) The TRPA1 blockers reduced the immunofluorescence intensity of NOX1 and Calpian1 on D3 in the ICH mice (n ≥ 3). (D,E) NOX1 and Calpain1 expression were reduced in the ICH mice after application of the TRPA1 blockers. The sham group was assessed on D3 after sham surgery (n ≥ 3). Scale bars represent 50 μm (*P < 0.05 vs. sham group, **P < 0.01 vs. sham group, #P < 0.05, ##P < 0.01).