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. 2019 Apr 23;10:1884. doi: 10.1038/s41467-019-09713-w

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — CpH methylation in hypothalamus of Dnmt3a^+/+ and Dnmt3a^Δ/D329A mice. a Representative genome browser view of CpH methylation in adult (14-week) male hypothalamus. Methylation levels appear to be dependent on the number of alleles present, with a decrease observed in Dnmt3a^∆/+ compared to Dnmt3a^+/+. Notably, there is an increase of methylation over hyper-DMR regions (highlighted by the box) in the presence of Dnmt3a^D329A. Each bar represents a 1000-CpH tile. For gene and mRNA tracks, the colour indicates direction, where red is a forward strand and blue is a reverse strand. CGI: CpG island, hyper-DMR: hypermethylated region. n(+/+, Δ/+, Δ/D329A) = 3, n(+/D329A) = 2. Error bars indicate standard deviation. b Global mean CpH methylation values across different genotypes. c Mean CpH methylation values over DMRs with CpG hypermethylation. b, c 1000-CpH tile quantitation for chromosomes 2 and 11 was used as representative. Error bars indicate standard error of the mean. Pairwise comparisons were done using a two-tailed t-test. Raw data are provided in Source Data. d Barplot indicating the net difference in mean CpH methylation between hyper-DMRs and global levels for Dnmt3a^+/+ and Dnmt3a ^Δ/D329A mice across development (E7.5 epiblast, P1, P25, and adult hypothalamus). Raw data are provided in Source Data